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Cnidarians Biomineral in Tissue Engineering: A Review

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Abstract

Biomineralization is the process by which organisms precipitate minerals. Crystals formed in this way are exploited by the organisms for a variety of purposes, including mechanical support and protection of soft tissue. Skeletal precipitation, via millions of years of evolution, has produced a wide variety of architectural configurations and material properties. It is exactly these properties that now attract the attention of researchers searching for new materials for a variety of biomedical applications.

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Abbreviations

ECM:

extracellular matrix

CNS:

central nervous system

MSCs:

mesenchymal stem cells

References

  • Abramovitch-Gottlib L, Geresh S, Vago R (2006) Biofabricated marine hydrozoan: a bioactive crystalline material promoting ossification of mesenchymal stem cells. Tissue Eng 12(4):729–739

    Article  PubMed  CAS  Google Scholar 

  • Achituv Y, Dubinsky Z (1990) Evolution and zoography of coral reefs. In: Dubinsky Z (ed) Coral reefs. Ecosystems of the world. vol. 25. Elsevier, Amsterdam, pp 1–9

    Google Scholar 

  • Aizenberg J, Sundar VC, Yablon AD, Weaver JC, Chen G (2004) Biological glass fibers: correlation between optical and structural properties. Proc Natl Acad Sci USA 101(10):3358–3363

    Article  PubMed  CAS  Google Scholar 

  • Al-Salihi KA (2004) Tissue-engineered bone via seeding bone marrow stem cell derived osteoblasts into coral: a rat model. Med J Malays 59(Suppl B):200

    Google Scholar 

  • Al-Salihi KA, Samsudin AR (2004a) Bone marrow mesenchymal stem cells differentiation and proliferation on the surface of coral implant. Med J Malays 59(Suppl B):45

    Google Scholar 

  • Al-Salihi KA, Samsudin AR (2004b) Coral-polyhydroxybutrate composite scaffold for tissue engineering: prefabrication properties. Med J Malays 59(Suppl B):202

    Google Scholar 

  • Anselme K (2000) Osteoblast adhesion on biomaterials. Biomaterials 21(7):667–681

    Article  PubMed  CAS  Google Scholar 

  • Aubin JE, Heersch JNM (2000) Osteoprogenitor cell differentiation to mature bone-forming osteoblasts. Drug Develop Res 49:206–215

    Article  CAS  Google Scholar 

  • Baranes D, Cove J, Blinder P, Shany B, Peretz H, Vago R (2007) Gigantic ganglion-like neural cell spheres formed on hydrozoan skeleton. Tissue Eng 13:473–482

    Google Scholar 

  • Barnes DJ, Chalker BE (1990) Calcification and photosynthesis in reef-building corals and algae. In: Dubinsky Z (ed) Coral reefs. Ecosystems of the world. vol. 25. Elsevier, Amsterdam, pp 109–131

    Google Scholar 

  • Ben-Nissan B, Milev A, Vago R (2004) Morphology of sol–gel derived nano-coated coralline hydroxyapatite. Biomaterials 25(20):4971–4975

    Article  PubMed  CAS  Google Scholar 

  • Bilezikian JP, Raisz LG, Rodan GA (eds) (2002) Principles of Bone Biology, Second edition. Academic Press, New York

  • Birk RZ, Abramovitch-Gottlib L, Margalit I, Aviv M, Forti E, Geresh S, Vago R (2006) Conversion of adipogenic to osteogenic phenotype using crystalline porous biomatrices of marine origin. Tissue Eng 12(1):21–31

    Article  PubMed  CAS  Google Scholar 

  • Brown RA (2002) Tissue engineering: clinical applications and mechanical control. In: Polak JM, Hench LL, Kemp P (eds) Future strategies for tissue and organ replacement. Imperial College, London, pp 51–78

    Google Scholar 

  • Damien CJ, Parsons JR (1991) Bone graft and bone graft substitutes: a review of current technology and applications. J Appl Biomater 2(3):187–208

    Article  PubMed  CAS  Google Scholar 

  • Demers C, Hamdy CR, Corsi K, Chellat F, Tabrizian M, Yahia L (2002) Natural coral exoskeleton as a bone graft substitute: a review. Biomed Mater Eng 12(1):15–35

    PubMed  Google Scholar 

  • Devecioglu D, Tozum TF, Sengun D, Nohutcu RM (2004) Biomaterials in periodontal regenerative surgery: effects of cryopreserved bone, commercially available coral, demineralized freeze-dried dentin, and cementum on periodontal ligament fibroblasts and osteoblasts. J Biomater Appl 19(2):107–120

    Article  PubMed  Google Scholar 

  • Dickson DW (2004) Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? J Clin Invest 114(1):23–27

    PubMed  CAS  Google Scholar 

  • Doherty MJ, Schlag G, Schwarz N, Mollan RA, Nolan PC, Wilson DJ (1994) Biocompatibility of xenogeneic bone, commercially available coral, a bioceramic and tissue sealant for human osteoblasts. Biomaterials 15(8):601–608

    Article  PubMed  CAS  Google Scholar 

  • Dowling JE (1992) Neurons and networks. Harvard University Press, London

    Google Scholar 

  • Ducy P, Schinke T, Karsenty G (2000) The osteoblast: a sophisticated fibroblast under central surveillance. Science 289(5484):1501–1504

    Article  PubMed  CAS  Google Scholar 

  • Evans GRD (2000) Challenges to nerve regeneration. Semin Surg Oncol 19(3):312–318

    Article  PubMed  CAS  Google Scholar 

  • Fitch MT, Silver J (1997) Glial cell extracellular aragonite template: boundaries for axon growth in development and regeneration. Cell Tissue Res 290:379

    Article  PubMed  CAS  Google Scholar 

  • Fricain JC, Bareille R, Ulysse F, Dupuy B, Amedee J (1998) Evaluation of proliferation and protein expression of human bone marrow cells cultured on coral crystallized in the aragonite of calcite form. J Biomed Mater Res 42:96

    Article  PubMed  CAS  Google Scholar 

  • Gravel M, Gross T, Vago R, Tabrizian M (2006) Responses of mesenchymal stem cell to chitosan–coralline composites microstructured using coralline as a gas forming agent. Biomaterials 27(9):1899–1906

    Article  PubMed  CAS  Google Scholar 

  • Green D, Walsh D, Mann S, Oreffo RO (2002) The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons. Bone 30(6):810–815

    Article  PubMed  CAS  Google Scholar 

  • Guillemin G, Meunier A, Dallant P, Christel P, Pouliquen JC, Sedel L (1989) Comparison of coral resorption and bone apposition with two natural corals of different porosities. J Biomed Mater Res 23:765

    Article  PubMed  CAS  Google Scholar 

  • Hou R, Chen FL, Yang YW, Cheng XB, Gao Z, Yang HWO, Wu W, Mao TQ (2007) Comparative study between coral–mesenchymal stem cells–rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model. J Biomed Mater Res A 80a(1):85–93

    Article  CAS  Google Scholar 

  • Hu J, Fraser R, Russell J, Ben-Nissan B, Vago R (2000) Australian coral as a biomaterial: characteristics. J Mater Sci Technol 16:591–602

    CAS  Google Scholar 

  • Langer R, Vacanti JP (1993) Tissue engineering. Science 260(5110):920–926

    Article  PubMed  CAS  Google Scholar 

  • LeGeros RZ (2002) Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res 395:81–98

    Article  PubMed  Google Scholar 

  • Lewis JB (2006) Biology and ecology of the hydrocoral Millepora on coral reefs. Adv Mar Biol 50:1–55

    Article  PubMed  Google Scholar 

  • Liao H, Mutvei H, Sjostrom M, Hammarstrom L, Li J (2000) Tissue responses to natural aragonite (Margaritifera shell) implants in vivo. Biomaterials 21:457

    Article  PubMed  CAS  Google Scholar 

  • Long MW (2001) Osteogenesis and bone-marrow-derived cells. Blood Cells Mol Dis 27(3):677–690

    Article  PubMed  CAS  Google Scholar 

  • Marks SC, Odgren PR (2002) In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. 2nd edn. Academic, New York

  • Martin RB, Burr DB, Sharkey NA (1998) Skeletal tissue mechanics. Springer, Berlin, pp 29–78

    Google Scholar 

  • Northington FJ, Graham EM, Martin LJ (2005) Apoptosis in perinatal hypoxicis-chemic brain injury: how important is it and should it be inhibited. Brain Res Rev 50(2):244–257

    PubMed  CAS  Google Scholar 

  • Ohgushi H (1997) Coral derived porous framework having different chemical compositions as a scaffold for osteoblastic differentiation. Porous Mat Tissue Eng Mat Sci Forum 250:209–220

    CAS  Google Scholar 

  • Ohgushi H, Okumura M, Yoshikawa T, Inoue K, Senpuku N, Tamai S, Shors EC (1992) Bone-formation process in porous calcium-carbonate and hydroxyapatite. J Biomed Mater Res 26(7):885–895

    Article  PubMed  CAS  Google Scholar 

  • Peretz H, Talpalar A, Vago R, Baranes D (2007) Hippocampal astrocytes and neurons grown on aragonite biomatrices have superior survival rate and durability than when grown in two-dimensional cultures. Tissue Eng 13:461–472

    Google Scholar 

  • Petite H, Viateau V, Bensaid W, Meunier A, de Pollak C, Bourguignon M, Oudina K, Sedel L, Guillemin G (2000) Tissue-engineered bone regeneration. Nat Biotechnol 18(9):959–963

    Article  PubMed  CAS  Google Scholar 

  • Phillips JB, Bunting SCJ, Hall SM, Brown RA (2005) Neural tissue engineering: a self-organizing collagen guidance conduit. Tissue Eng 11(9–10):1611–1617

    Article  PubMed  CAS  Google Scholar 

  • Reier PJ, Houle JD (1988) The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair. Adv Neurol 47:87

    PubMed  CAS  Google Scholar 

  • Rodan GA (1992) Introduction to bone biology. Bone 13(Suppl 1):S3–S6

    Article  PubMed  CAS  Google Scholar 

  • Roudier M, Bouchon C, Rouvillain JL, Amedee J, Bareille R, Rouais F, Fricain JC, Dupuy B, Kien P, Jeandot R et al (1995) The resorption of bone-implanted corals varies with porosity but also with the host reaction. J Biomed Mater Res 29(8):909–915

    Article  PubMed  CAS  Google Scholar 

  • Ruppert EE, Barnes RD (1994) Invertebrate zoology, 6th edn. Saunders College, Philadelphia

    Google Scholar 

  • Schmidt CE, Leach JB (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 5:293

    Article  PubMed  CAS  Google Scholar 

  • Shany B, Peretz H, Blinder P, Lichtenfeld Y, Jeger R, Vago R, Baranes D (2006) Aragonite crystalline biomatrices support astrocytic tissue formation in vitro and in vivo. Tissue Eng 12:1763–1773

    Article  PubMed  CAS  Google Scholar 

  • Shany B, Vago R, Baranes D (2005) Growth of primary hippocampal neuronal tissue on aragonite crystalline biomatrix. Tissue Eng 11:586–596

    Article  Google Scholar 

  • Sikavitsas VI, Temenoff JS, Mikos AG (2001) Biomaterials and bone mechanotransduction. Biomaterials 22(19):2581–2593

    Article  PubMed  CAS  Google Scholar 

  • Simkiss K, Wilbur KM (eds) (1989) Biomineralization. Academic, New York

  • Sundar VC, Yablon AD, Grazul JL, Ilan M, Aizenberg J (2003) Fibre-optical features of a glass sponge—some superior technological secrets have come to light from a deep-sea organism. Nature 424:899–900

    Article  PubMed  CAS  Google Scholar 

  • Tian WM, Hou SP, Ma J, Zhang CL, Xu QY, Lee IS, Li HD, Spector M, Cui FZ (2005) Hyaluronic acid-poly-D-lysine-based three-dimensional hydrogel for traumatic brain injury. Tissue Eng 11(3–4):513–525

    Article  PubMed  CAS  Google Scholar 

  • Vago R, Shai Y, Benzion M, Dubinsky Z, Achituv Y (1994) Computerized-tomography and image-analysis. A tool for examining the skeletal characteristics of reef-building organisms. Limnol Oceanogr 39:448

    Google Scholar 

  • Vago R, Gill E, Collingwood JC (1997) Laser measurements of coral growth. Nature 386(6620):30–31

    Article  CAS  Google Scholar 

  • Vago R, Achituv Y, Vaky L, Dubinsky Z, Kizner Z (1998) Colony architecture of Millepora dichotoma. Forskal J Exp Mar Biol Ecol 224:225

    Article  Google Scholar 

  • Vago R, Plotquin D, Bunin A, Sinelnikov I, Atar D, Itzhak D (2002) Hard tissue remodeling using biofabricated coralline biomaterials. J Biochem Biophys Methods 50(2–3):253–259

    Article  PubMed  CAS  Google Scholar 

  • Vuola J, Bohling T, Kinnunen J, Hirvensalo E, Asko-Seljavaara S (2000) Natural coral as bone-defect-filling material. J Biomed Mater Res 51(1):117–122

    Article  PubMed  CAS  Google Scholar 

  • Weiner S, Addadi L (1997) Design strategies in mineralized biological materials. J Mater Chem 7(5):689–702

    Article  CAS  Google Scholar 

  • Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG (1996) Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone. Biomaterials 17(2):175–185

    Article  PubMed  CAS  Google Scholar 

  • Zhang N, Yan HH, Wen XJ (2005) Tissue-engineering approaches for axonal guidance. Brain Res Rev 49(1):48–64

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The author thanks Dr. L. Abramovitch-Gottlib, Ms. T. Gross-Aviv, Ms. L. Segal, Ms. H. Peretz, and Ms.L. Astachov for their support and Ms. I. Mureinik for critically reviewing the manuscript.

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  1. Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel

    Razi Vago

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  1. Razi Vago
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Correspondence to Razi Vago.

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Vago, R. Cnidarians Biomineral in Tissue Engineering: A Review. Mar Biotechnol 10, 343–349 (2008). https://doi.org/10.1007/s10126-008-9103-z

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