Skip to main content
SpringerLink
Log in

Influence of different types of electromagnetic fields on skin reparatory processes in experimental animals

  • Original Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

Abstract

Wound healing is a very complex process, some phases of which have only recently been explained. Magnetic and electromagnetic fields can modulate this process in a non-thermal way. The aim of this research was to compare the influence of constant and pulsed electromagnetic fields and low-level laser therapy (LLLT) on wound healing in experimental animals. The experiment was conducted on 120 laboratory rats divided into four groups of 30 animals each (constant electromagnetic field, pulsed electromagnetic field, LLLT and control group). It lasted for 21 days. Under the influence of the constant electromagnetic field the healing of the skin defect was accelerated in comparison with the control group. The difference was statistically significant in all the weeks of the experiment at the P < 0.01 level. Accelerated healing was also observed under the influence of the pulsed electromagnetic field (P < 0.05). In the group of animals exposed to LLLT, the healing of the skin defect was faster than in the control group. The statistical significance was at the P < 0.05 level. Different types of electromagnetic fields have a promoting effect on the wound healing process.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Harris DM (1988) Laser biostimulation: Review and hypothesis. Laser Topics 10:9–14

    Google Scholar 

  2. Karu TI (2003) Low power laser therapy. In: Biomedical photonics handbook. Tuan Vo-Dinh, CRC Press, Boca Raton, pp 48–25

  3. Karu T (1989) Photobiology of low-power laser effects. Health Physics 56:691–704

    Article  CAS  PubMed  Google Scholar 

  4. Bassett CA (1993) Beneficial effects of electromagnetic fields. J Cell Biochem 51:387–393

    Article  CAS  PubMed  Google Scholar 

  5. Markov MS (2007) Pulsed electromagnetic field therapy history, state of the art and future. Environmentalist 27:465–475

    Article  Google Scholar 

  6. Quittan M, Schuhfried O, Wiesinger GF, Fialka-Moser V (2000) Clinical effectiveness of magnetic field therapy—a review of the literature. Acta Med Austriaca 27:61–68

    Article  CAS  PubMed  Google Scholar 

  7. Stefanovska A, Vodovnik L, Benko H, Turk R (1993) Treatment of chronic wounds by means of electric and electromagnetic fields. Part 2. Value of FES parameters for pressure sore treatment. Med Biol Eng Comput 31:213–220

    CAS  PubMed  Google Scholar 

  8. Saha S, Campbell CE, Johnson JP (1997) Effect of electrical stimulation of wound healing: a review. In: Andersen JB, Barsani F, Blank M, O’Connor ME (eds) Second world congress for electricity and magnetism in biology and medicine, 8–13 June, Bologna, p 309

  9. Man D, Man B, Plosker H, Markov M (1997) Effect of permanent magnetic field on postoperative pain and wound healing in plastic surgery. In: Andersen JB, Barsani F, Blank M, O’Connor ME (eds) Second world congress for electricity and magnetism in biology and medicine, 8–13 June 1997, Bologna, p 310

  10. Lazetic B (1989) Physiological basics of the influence the therapeutic electromagnetic fields. In: Sep D (ed) Electrobiological induction of osteogenesis. Novi Sad, Yugoslavia, pp 17–26

  11. Canedo-Dorantes L, Garcia-Cantu R, Barrera R, Mendez-Ramirez I, Navarro VH, Serrano G (2002) Healing of chronic arterial and venous leg ulcers through systemic effects of electromagnetic fields. Arch Med Res 33:281–289

    Article  PubMed  Google Scholar 

  12. Lažetić B, Kozarčić T, Stankov K (1997) The effect of low-frequency electromagnetic fields on the neuroendocrine system. Med Pregl 50:357–362

    PubMed  Google Scholar 

  13. Ueno S, Iwasaka M (1997) Effects and mechanisms of intense DC magnetic fields on biological, physical and chemical processes. In: Andersen JB, Barsani F, Blank M, O’Connor ME (eds) Second world congress for electricity and magnetism in biology and medicine, 8–13 June 1997, Bologna, p 66

  14. Kholodov YA, Artyuhina NL, Lebedeva NN (1989) Nervous system reactions to magnetic fields. In: Guseo A (ed) Second Hungarian symposium on magneto-therapy, 16–17 May 1987, Szekesfehervar, pp 122–123

  15. Ottani V, DePasquale P, Franchi M, Zaniol P, Ruggeri A (1988) Effects of pulsed extremely-low-frequency magnetic fields on skin wounds in the rat. Bioelectromagnetics 9:53–62

    Article  CAS  PubMed  Google Scholar 

  16. Ieran M, Zaffuto S, Bagnacani M, Annovi M, Moratti A, Cadossi R (1990) Effect of low frequency pulsing electromagnetic fields on skin ulcers of venous origin in humans: a double-blind study. J Orthop Res 8:276–282

    Article  CAS  PubMed  Google Scholar 

  17. Patino O, Grana D, Bolgiani A, Prezzavento G, Mino J, Merlo A, Benaim F (1996) Pulsed electromagnetic fields in experimental cutaneous wound healing in rats. J Burn Care Rehabil 17:528–531

    Article  CAS  PubMed  Google Scholar 

  18. Patino O, Grana D, Bolgiani A, Prezzavento G, Merlo A (1996) Effect of magnetic fields on skin wound healing. Experimental study. Medicina B Aires 56:41–44

    CAS  PubMed  Google Scholar 

  19. Strauch B, Patel MK, Navarro JA, Berdichevsky M, Yu HL, Pilla AA (2007) Pulsed magnetic fields accelerate cutaneous wound healing in rats. Plast Reconstr Surg 120:425–430

    Article  CAS  PubMed  Google Scholar 

  20. Djuran V, Zamurović A, Stojanović S, Poljački M, Jovanović M, Đurišić S (1991) Therapy of venous ulcers using pulsating EMFs: personal results. Med Pregl 44:485–488

    Google Scholar 

  21. Stiller MJ, Grace HP, Shupak JH, Thaler S, Kenny C, Jondreau L (1992) A portable pulsed electromagnetic field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double-blind, placebo-controlled clinical trial. Br J Dermatol 127:147–154

    Article  CAS  PubMed  Google Scholar 

  22. Salzberg CA, Cooper Vastola SA, Perez F, Viehbeck MG, Byrne DW (1995) The effects of non-thermal pulsed electromagnetic energy on wound healing of pressure ulcers in spinal cord-injured patients: a randomised, double-blind study. Ostomy Wound Manage 41:42–44

    CAS  PubMed  Google Scholar 

  23. Comorosan S, Vasilco R, Arghiropol M, Paslaru L, Jieanu V, Stelea S (1993) The effect of diapulse therapy on the healing of decubitus ulcer. Rom J Physiol 30:41–45

    CAS  PubMed  Google Scholar 

  24. Matic M, Lazetic B, Poljacki M, Djuran V, Ivkov-Simic M (2003) Low level laser irradiation and its effect on repair processes in the skin. Med Pregl 56:137–141

    Article  PubMed  Google Scholar 

  25. Schindl A, Merwald H, Schindl L, Kaun C, Wojta J (2003) Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation. Br J Dermatol 148:334–336

    Article  CAS  PubMed  Google Scholar 

  26. Bisht D, Gupta SC, Misra V, Mital VP, Sharma P (1994) Effect of low intensity laser radiation on healing of open skin wounds in rats. Indian J Med Res 100:43–46

    CAS  PubMed  Google Scholar 

  27. Ismailov DA, Khoroshaev VA, Shishkin MA, Baibekov IM (1993) Combined use of various laser radiations in thoracic surgery in experimental studies. Grud Serdechnososudistaia Khir 4:42–45

    PubMed  Google Scholar 

  28. Ribeiro MS, Da Silva Dde F, De Araujo CE, De Oliveira SF, Pelegrini CM, Zorn TM, Zezell DM (2004) Effects of low-intensity polarized visible laser radiation on skin burns: a light microscopy study. J Clin Laser Med Surg 22:59–66

    Article  PubMed  Google Scholar 

  29. Reddy GK (2003) Comparison of the photostimulatory effects of visible He-Ne and infrared Ga-As lasers on healing impaired diabetic rat wounds. Lasers Surg Med 33:344–351

    Article  PubMed  Google Scholar 

  30. Allendorf JD, Bessler M, Huang J, Kayton ML, Laird D, Nowygrod R, Treat MR (1997) Helium-neon laser irradiation at fluences of 1, 2, and 4 J/cm2 failed to accelerate wound healing as assessed by both wound contracture rate and tensile strength. Lasers Surg Med 20:340–345

    Article  CAS  PubMed  Google Scholar 

  31. Kleiman Y, Simmor S, Braksma Y, Morag B, Lichtenstein D (1996) Low level laser therapy in patients with venous ulcers: early and long-term outcome. Laser Ther 8:205–208

    Article  Google Scholar 

  32. Surgue ME, Carolan J, Leen EJ, Feeley TM, Moore DJ, Shanik GD (1990) The use of infrared laser therapy in the treatment of venous ulceration. Ann Vasc Surg 4:179–181

    Article  Google Scholar 

  33. Matić M, Djuran V, Poljački M, Jovanović M, Subotić M (1996) Our preliminary results of therapy of lower leg venous ulcers with Ga-As laser. Acta dermatovenerol Iugosl. XV congress of dermatovenereologists of Yugoslavia with international participation. 30 October–2 November 1996, Belgrade 19 [Suppl]:50

    Google Scholar 

Download references

Acknowledgement

This research was partly financed by the Ministry of Science of the Republic of Serbia, as part of the “Influence of non-ionising radiation,–magnetic, electromagnetic, on biological systems” project.

Author information

Authors and Affiliations

  1. Dermatovenereological Clinic, Clinical Centre of Vojvodina, Hajduk Veljkova 1s7, Novi Sad, 21000, Serbia

    Milan Matic, Mirjana Poljacki, Verica Djuran & Zorica Gajinov

  2. Physiology Department, Medical Faculty Novi Sad, Hajduk Veljkova 1s7, Novi Sad, 21000, Serbia

    Bogosav Lazetic

  3. Pediatric Clinic, Institute for Health Protection of Children and Youth of Vojvodina, Hajduk Veljkova 10, Novi Sad, 21000, Serbia

    Aleksandra Matic

Authors
  1. Milan Matic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bogosav Lazetic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mirjana Poljacki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Verica Djuran
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Aleksandra Matic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Zorica Gajinov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Milan Matic.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matic, M., Lazetic, B., Poljacki, M. et al. Influence of different types of electromagnetic fields on skin reparatory processes in experimental animals. Lasers Med Sci 24, 321–327 (2009). https://doi.org/10.1007/s10103-008-0564-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-008-0564-0

Keywords

Search

Navigation