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Aberrant default mode network in amnestic mild cognitive impairment: a meta-analysis of independent component analysis studies

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Abstract

Independent component analysis (ICA) is one of the most popular and valid methods to investigate the default mode network (DMN), an intrinsic network which attracts particular attention in amnestic mild cognitive impairment (aMCI). However, previous studies present inconsistent results regarding the topographical organization of the DMN in aMCI. Therefore, we conducted a quantitative, voxel-wise meta-analysis of resting-state ICA studies using Seed-based d Mapping to establish the most consistent pattern of DMN functional connectivity alterations in aMCI. Twenty studies, comprising 23 independent datasets involving 535 patients and 586 healthy controls, met the inclusion criteria. Patients with aMCI exhibited reliably lower DMN functional connectivity than the healthy controls in the bilateral precuneus/posterior cingulate cortices and medial temporal lobes, which are implicated in episodic memory deficits. Moreover, an exploratory meta-regression analysis revealed that greater severity of global cognitive impairment in the patient groups was associated with stronger functional connectivity in the bilateral medial frontal cortices (including the anterior cingulate cortices), left angular gyrus, and right temporal pole extending to the middle temporal gyrus, likely reflecting a compensatory mechanism for maintaining cognitive efficiency. This meta-analysis identifies a consistent pattern of aberrant DMN functional connectivity in aMCI, which facilitates understanding of the neurobiological substrates of this disease.

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Abbreviations

AD:

Alzheimer’s disease

aMCI:

amnestic mild cognitive impairment

ACC:

anterior cingulate cortices

AVLT:

Auditory Verbal Learning Test

DMN:

default mode network

FWHM:

full width at half maximum

ICA:

independent component analysis

IPL:

inferior parietal lobules

MNI:

Montreal Neurological Institute

MTL:

medial temporal lobe

MOOSE:

Meta-analysis Of Observational Studies in Epidemiology

MMSE:

Mini-Mental State Examination

PCC:

posterior cingulate cortices

SDM:

Seed-based d Mapping

SMD:

standardized mean difference

rs-fMRI:

resting-state functional magnetic resonance imaging

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Acknowledgements

We thank all the authors of the included studies.

Author information

Author notes

  1. ChunLei Wang and Yuan Pan contributed equally to this study.

Authors and Affiliations

  1. Encephalopathy Center, The First Clinical Medical College, Nanjing University of Chinese Medicine, 210023, 138 Xianlin Rd, Nanjing, People’s Republic of China

    ChunLei Wang, Juan Ke & WeiFeng Guo

  2. Department of Endocrinology, Yancheng City No.1 People’s Hospital, Yancheng, People’s Republic of China

    ChunLei Wang, YanMei Liu, Ke Xu, LanXiang Hao & Fei Huang

  3. Department of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, People’s Republic of China

    Yuan Pan

  4. Department of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, People’s Republic of China

    LiQin Sheng & HaiRong Ma

Authors
  1. ChunLei Wang
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  2. Yuan Pan
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  3. YanMei Liu
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  4. Ke Xu
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  5. LanXiang Hao
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  6. Fei Huang
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  7. Juan Ke
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  8. LiQin Sheng
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  9. HaiRong Ma
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  10. WeiFeng Guo
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Corresponding author

Correspondence to WeiFeng Guo.

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Wang, C., Pan, Y., Liu, Y. et al. Aberrant default mode network in amnestic mild cognitive impairment: a meta-analysis of independent component analysis studies. Neurol Sci 39, 919–931 (2018). https://doi.org/10.1007/s10072-018-3306-5

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  • DOI: https://doi.org/10.1007/s10072-018-3306-5

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