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Anti-diabetic potential of a Sasa quelpaertensis Nakai extract in L6 skeletal muscle cells

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Abstract

The anti-diabetic potential of a Sasa quelpaertensis Nakai extract (SQE) in L6 muscle cells was evaluated. The SQE stimulated glucose uptake via the AMP-activated protein kinase-activating pathway, but not via the insulinstimulating pathway. The SQE increased the expression of fatty acid translocase and peroxisome proliferator-activated receptor γ, and induced phosphorylation of acetyl-CoA carboxylase. The SQE attenuated oleic acid-induced intracellular triglyceride contents by decreasing the expression of sterol regulatory element-binding protein-1c and fatty acid synthase. These results indicate that the SQE probably has an anti-diabetic potential by enhancing glucose uptake and reducing triglyceride content in L6 skeletal muscle cells.

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Authors and Affiliations

  1. Department of Biology, Jeju National University, Jeju, 690-756, Korea

    Seon-A Yoon, Seong-Il Kang, Hye-Sun Shin & Se-Jae Kim

  2. Jeju Sasa Industry Development Agency, Jeju National University, Jeju, 690-756, Korea

    Hee-Chul Ko & Se-Jae Kim

Authors
  1. Seon-A Yoon
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  2. Seong-Il Kang
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  3. Hye-Sun Shin
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  4. Hee-Chul Ko
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  5. Se-Jae Kim
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Correspondence to Se-Jae Kim.

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Yoon, SA., Kang, SI., Shin, HS. et al. Anti-diabetic potential of a Sasa quelpaertensis Nakai extract in L6 skeletal muscle cells. Food Sci Biotechnol 23, 1335–1339 (2014). https://doi.org/10.1007/s10068-014-0183-4

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  • DOI: https://doi.org/10.1007/s10068-014-0183-4

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