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Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice

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Abstract

The antidiabetogenic and antioxidative effects of octaphlorethol A (OPA) isolated from the brown algae Ishige foliacea in streptozotocin (STZ)-induced diabetic mice were analyzed. STZ-induced diabetic mice showed a significant (p<0.05) increase in blood glucose and lipid peroxidation levels and a significant (p<0.05) decrease in the plasma insulin level and body weight, compared with controls. Diabetic mice also showed a significant (p<0.05) decrease in the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-px), compared with controls. Oral treatment with OPA (5 and 10 mg/kg) showed protective effects against all the biochemical parameters studied. OPA-treated mice exhibited suppression of apoptosis, and treatment with OPA was associated with an increase in antiapoptotic BclxL expression and a reduction in pro-apoptotic Bax and cleaved caspase-3 expressions. OPA has antidiabetogenic and antioxidative effects, and potential for use in therapies as both a natural functional food and a pharmaceutical agent.

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Authors and Affiliations

  1. Division of Food Bioscience, Konkuk University, Chungju, Chungbuk, 380-701, Korea

    Seung-Hong Lee

  2. Department of Marine Life Science, Jeju National University, Jeju, 690-756, Korea

    Nalae Kang, Eun-A Kim & You-Jin Jeon

  3. Global Bioresources Research Center, Korea Institute of Ocean Science & Technology, Ansan, Gyeonggi, 426-744, Korea

    Soo-Jin Heo

  4. Korea Nokyong Research Center, Konkuk University, Chungju, Chungbuk, 380-701, Korea

    Sang-Ho Moon & Byong-Tae Jeon

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  1. Seung-Hong Lee
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  2. Nalae Kang
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  4. Soo-Jin Heo
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Correspondence to You-Jin Jeon.

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Lee, SH., Kang, N., Kim, EA. et al. Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice. Food Sci Biotechnol 23, 1261–1266 (2014). https://doi.org/10.1007/s10068-014-0173-6

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  • DOI: https://doi.org/10.1007/s10068-014-0173-6

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