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Antihyperglycemic and antioxidant activities of total alkaloids from Catharanthus roseus in streptozotocin-induced diabetic rats

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Abstract

We evaluated the hypoglycemic and antioxidant effects of the total alkaloids of leaves and twigs of Catharanthus roseus Linn. (CTA) in streptozotocin (STZ)-induced diabetic rats. The hypoglycemic effect was measured by blood glucose and plasma insulin level. Oxidative stress was measured in heart, liver and kidney by levels of antioxidant markers, free radical scavengers and lipid peroxides i.e. superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). Biochemical parameters, i.e. aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphate (ALP) were observed in diabetic control and treated rats. Oral administration of CTA for 30 days was followed by a significant (P < 0.05) decrease in fasting blood glucose and increase in insulin level as compared with untreated diabetic rats. Also it significantly (P < 0.05) reduced ALT, AST and ALP. The treatment also resulted in significant (P < 0.05) reductions in GSH, SOD, CAT, and decrease in TBARS in the heart, liver and kidney of diabetic rats. The results suggest that CTA can effectively normalize the impaired antioxidant status in STZ-induced diabetes in a dose-dependent manner. CTA exerted rapid protective effects against lipid peroxidation by scavenging of free radicals and reducing the risk of diabetic complications.

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Acknowledgments

We acknowledgment the Fundamental Research Funds for the Special Fund for Forestry Scientific Research in the Public Interest (201304601) for financial support.

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Authors and Affiliations

  1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, People’s Republic of China

    Lin Zhang, Gang Wei, Yang Liu, Yuangang Zu, Qinghui Gai & Lei Yang

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  1. Lin Zhang
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  2. Gang Wei
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  3. Yang Liu
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  4. Yuangang Zu
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  5. Qinghui Gai
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  6. Lei Yang
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Correspondence to Yuangang Zu.

Additional information

Project funding: This work was supported by the Fundamental Research Funds for the Special Fund for Forestry Scientific Research in the Public Interest (201304601).

The online version is available at http://www.springerlink.com

Corresponding editor: Zhu Hong

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Zhang, L., Wei, G., Liu, Y. et al. Antihyperglycemic and antioxidant activities of total alkaloids from Catharanthus roseus in streptozotocin-induced diabetic rats. J. For. Res. 27, 167–174 (2016). https://doi.org/10.1007/s11676-015-0112-2

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  • DOI: https://doi.org/10.1007/s11676-015-0112-2

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