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Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells

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Abstract

Chlorogenic acid (CGA) is one of the most abundant polyphenols in the human diet and has various biological properties such as antimicrobial and antioxidant activities. Although the biophysiological effects of CGA are well studied, its effect on stem cell differentiation has not been observed until recently. In this study, it was demonstrated that CGA promotes osteogenesis in human adipose tissue-derived mesenchymal stem cells (hAMSCs), as indicated by increased mineralization. The mRNA levels of alkaline phosphatase and runt-related transcription factor 2 increased significantly following treatment with 30 μM CGA. These results suggest a novel effect of CGA on osteogenic differentiation in hAMSCs and the possibility that CGA might affect the differentiation of other types of stem cells.

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Authors and Affiliations

  1. Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong, Chungbuk, 368-701, Korea

    Hee-Shin Bin, Jae-Hyun Jeong & Ung-Kyu Choi

  2. Daewon Food Service Co., Jincheon, Chungbuk, 365-823, Korea

    Hee-Shin Bin

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  1. Hee-Shin Bin
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  2. Jae-Hyun Jeong
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Correspondence to Ung-Kyu Choi.

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Bin, HS., Jeong, JH. & Choi, UK. Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells. Food Sci Biotechnol 22 (Suppl 1), 107–112 (2013). https://doi.org/10.1007/s10068-013-0055-3

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  • DOI: https://doi.org/10.1007/s10068-013-0055-3

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