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Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity

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Abstract

The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). A total of 61 RA patients and 27 healthy controls were recruited in this study. Serum samples were obtained from all subjects to determine the serum COMP levels. All subjects had bilateral ultrasound scan of their knees. The KCT was based on the mean of measurements at three sites: the medial condyle, lateral condyle and intercondylar notch. Besides, the RA patients were assessed for their disease activity based on 28-joint-based Disease Activity Score (DAS 28). Serum COMP concentrations were significantly elevated in the RA patients compared to the controls (p = 0.001). The serum COMP levels had an inverse relationship with bilateral KCT in RA subjects and the healthy controls. COMP correlated significantly with disease activity based on DAS 28 (r = 0.299, p = 0.010), disease duration (r = 0.439, p = < 0.05) and mean left KCT (r = − 0.285, p = 0.014) in RA. The correlation between serum COMP and DAS 28 scores was comparable to the traditional markers of inflammation: erythrocyte sedimentation rate (ESR) (r = 0.372, p = 0.003) and C-reactive protein (CRP) (r = 0.305, p = 0.017). The serum COMP is a promising biomarker in RA which reflects disease activity and damage to the articular cartilage.

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Acknowledgements

This study was funded by a research grant (IP-2014-053) provided by Universiti Kebangsaan Malaysia.

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Authors and Affiliations

  1. Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia

    Rajalingham Sakthiswary

  2. Department of Medicine, Putrajaya Hospital, Pusat Pentadbiran Kerajaan Persekutuan Presint 7, 62250, Putrajaya, Malaysia

    Shamala Rajalingam & Heselynn Hussein

  3. Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia

    Radhika Sridharan

  4. Department of Microbiology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia

    Abdul Wahab Asrul

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  1. Rajalingham Sakthiswary
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  2. Shamala Rajalingam
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  4. Radhika Sridharan
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  5. Abdul Wahab Asrul
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Correspondence to Rajalingham Sakthiswary.

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Sakthiswary, R., Rajalingam, S., Hussein, H. et al. Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity. Clin Rheumatol 36, 2683–2688 (2017). https://doi.org/10.1007/s10067-017-3817-0

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  • DOI: https://doi.org/10.1007/s10067-017-3817-0

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