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Recent developments in strontium-based biocomposites for bone regeneration

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  • Biomaterials
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Abstract

Recent advances in biomaterial designing techniques offer immense support to tailor biomimetic scaffolds and to engineer the microstructure of biomaterials for triggering bone regeneration in challenging bone defects. The current review presents the different categories of recently explored strontium-integrated biomaterials, including calcium silicate, calcium phosphate, bioglasses and polymer-based synthetic implants along with their in vivo bone formation efficacies and/or in vitro cell responses. The role and significance of controlled drug release scaffold/carrier design in strontium-triggered osteogenesis was also comprehensively described. Furthermore, the effects of stem cells and growth factors on bone remodeling are also elucidated.

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Acknowledgements

This research was supported by Zhejiang Provincial Natural Science Foundation of China (LY18H060013), Medical and Health Research Project of Zhejiang, Province (2019KY225), Science and Technology Project of Shaoxing (2018C30077, 2018C30082, 2018C30165).

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  1. Songou Zhang and Yongqiang Dong are first authors with equal contributions.

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  1. Shaoxing University School of Medicine, No. 900 Chengnan Avenue, Yuecheng District, Shaoxing, 312000, Zhejiang, People’s Republic of China

    Songou Zhang, Meikai Chen, Yifan Xu, Jianfeng Ping & Wangzhen Chen

  2. Department of Orthopaedics, Xinchang People’s Hospital, Shaoxing, 312500, Zhejiang, People’s Republic of China

    Yongqiang Dong

  3. Shaoxing People’s Hospital, The First Affiliated Hospital of Shaoxing University, 568# Zhongxing North Road, Shaoxing, 312000, Zhejiang, People’s Republic of China

    Wenqing Liang

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Zhang, S., Dong, Y., Chen, M. et al. Recent developments in strontium-based biocomposites for bone regeneration. J Artif Organs 23, 191–202 (2020). https://doi.org/10.1007/s10047-020-01159-y

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