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Oxidation and determination of Gabapentin on nanotubes of nickel oxide-modified carbon paste electrode

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Abstract

The electrooxidation of Gabapentin was studied on nanotubes of nickel oxide-modified carbon paste electrode for the first time. Cyclic voltammetry was employed to investigate the electrooxidation process. A simple, sensitive, and efficient amperometric method was developed for the analysis of the drug, and the corresponding analytical parameters were reported. For Gabapentin, a detection limit of 0.3 μM was obtained in a linear range of 2.4–50 μM. The proposed amperometric method was also applied to the analysis of commercial capsules, and the results were in good agreement with the declared values. Also, the applicability of the method to the direct assay of the drug in human serum and urine was described.

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Acknowledgments

We would like to thank the Iran National Science Foundation (INSF), the Research Councils of Islamic Azad University, Shiraz University of Medical Sciences, and K. N. Toosi University of Technology for supporting this research.

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Authors and Affiliations

  1. Laboratory of Analytical and Physical Electrochemistry, Department of Chemistry, Science and Research Branch, Islamic Azad University, Fars, Iran

    Hossein Heli

  2. Young Researchers Club, Science and Research Branch, Islamic Azad University, Fars, Iran

    Hossein Heli

  3. Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran

    F. Faramarzi

  4. Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran

    N. Sattarahmady

Authors
  1. Hossein Heli
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  2. F. Faramarzi
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  3. N. Sattarahmady
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Correspondence to Hossein Heli.

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Heli, H., Faramarzi, F. & Sattarahmady, N. Oxidation and determination of Gabapentin on nanotubes of nickel oxide-modified carbon paste electrode. J Solid State Electrochem 16, 45–52 (2012). https://doi.org/10.1007/s10008-010-1272-9

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  • DOI: https://doi.org/10.1007/s10008-010-1272-9

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