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Simultaneous voltammetric determination of rizatriptan and acetaminophen using a carbon paste electrode modified with NiFe2O4 nanoparticles

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Abstract

Nickel-ferrite nanoparticles (NiFe2O4) were synthesized by a hydrothermal method. They were used to modify a carbon paste electrode (CPE) and to prepare an electrochemical sensor for simultaneous determination of rizatriptan benzoate (RZB) and acetaminophen (AC). The structure and morphology of the bare CPE and modified CPE were studied using field emission scanning electron microscopy, while the structural characterization of NiFe2O4 was performed via X-ray diffraction. In the potential range 0.2–1.2 V, AC and RZB were detected at potentials of 0.5 V and 0.88 V (vs. Ag/AgCl saturated KCl 3 M), respectively. Both calibration plots are linear in the 1 to 90 μM concentration range. The limits of detection (at 3σ) of AC and RZB are 0.49 and 0.44 μM, respectively. The performance of the modified CPE was evaluated by quantifying the two drugs in spiked urine and in tablets.

The modified electrode consist of Nickel-ferrite and graphite by differential pulse voltammetry methods are schematically presented for simultaneous detection of acetaminophen (a painkiller drug) and rizatriptan benzoate (an antimigraine drug) in human urine and tablet samples.

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Acknowledgments

The authors acknowledge the Biofuel & Renewable Energy Research Center, Babol Noshirvani University of Technology, Babol, Mazandaran, Iran.

Funding

This study was funded by Babol Noshirvani University of Technology with the grant number of BNUT/945990012/1396.

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Authors and Affiliations

  1. Biofuel & Renewable Energy Research Center, Department of Biotechnology, Faculty of Chemical Engineering, Babol Noshirvani University of Technology Babol, Mazandaran, Iran

    Maedeh Nouri & Mostafa Rahimnejad

  2. Chemical Engineering Department, Babol Noshirvani University of Technology, Babol, Mazandaran, Iran

    Mostafa Rahimnejad

  3. Biotechnology Research Laboratory, Faculty of Chemical Engineering., Babol Noshirvani University of Technology, Babol, Iran

    Ghasem Najafpour

  4. Faculty of Pharmacology, Babol University of Medical Sciences, Babol, Iran

    Ali Akbar Moghadamnia

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  1. Maedeh Nouri
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  3. Ghasem Najafpour
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  4. Ali Akbar Moghadamnia
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Correspondence to Mostafa Rahimnejad.

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The authors had no conflict of interest. All procedures performed involving one human participant was in accordance with the ethical standards of the institutional and national research committee. Informed consent was obtained from the individual participant included in our study. Identifying information about the individual participant was not obtained.

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Nouri, M., Rahimnejad, M., Najafpour, G. et al. Simultaneous voltammetric determination of rizatriptan and acetaminophen using a carbon paste electrode modified with NiFe2O4 nanoparticles. Microchim Acta 187, 315 (2020). https://doi.org/10.1007/s00604-020-04290-y

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