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Structural and molecular properties of complexes of biomolecules and metal–organic frameworks: dispersion-corrected DFT treatment

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Abstract

Investigation of complexes of nanostructured materials and biomolecules has attracted much attention by various researchers as it can contribute to coherent growth and extended application of nanostructures in different technologies. In this research, following a comprehensive approach, we examined the interaction between different amino acids and metal–organic frameworks (MOFs) at atomic scale using computational chemistry. For this purpose, we employed the density functional theory (DFT-D2) calculations to afford a molecular description of the interaction properties of the amino acids and MOF-5 by examining the interaction energy and the electronic structure of the amino acid/MOF complexes. We found strong interactions between the amino acids and MOF through their polar groups as well as aromatic rings in the gas phase. However, our findings were significantly different in solvent media, where water molecules prevent the amino acids from approaching the active sites of MOF, causing weak attractions between them. The evaluation of nature of interaction between the amino acids and MOF by the atoms-in-molecules (AIM) theory shows that the electrostatic attractions are the main force contributing to bond formation between the interacting entities. Furthermore, our DFT-PBE model of theory was validated against the comprehensive MP2 quantum level of theory.

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Authors and Affiliations

  1. Department of Chemical Engineering, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Anahita Bakhshandeh, Fatemeh Ardestani & Hamid Reza Ghorbani

  2. Department of Nanochemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Masoud Darvish Ganji

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  1. Anahita Bakhshandeh
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  2. Fatemeh Ardestani
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  3. Hamid Reza Ghorbani
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  4. Masoud Darvish Ganji
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Contributions

MDG and FA planned the project, AB and MDG build the models and set up the software, HRG and MDG analyzed the results, AB, FA, and MFG participated in the manuscript preparation.

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Correspondence to Fatemeh Ardestani or Masoud Darvish Ganji.

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Bakhshandeh, A., Ardestani, F., Ghorbani, H.R. et al. Structural and molecular properties of complexes of biomolecules and metal–organic frameworks: dispersion-corrected DFT treatment. J Mol Model 28, 32 (2022). https://doi.org/10.1007/s00894-021-04947-2

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