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Genetic polymorphisms are involved in oral health–related quality of life in skeletal class III patients submitted to orthognathic surgery

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Abstract

Objective

This study aimed to evaluate whether sex and genetic polymorphisms impact the oral health–related quality of life (OHRQoL) preoperatively and the difference between preoperative and postoperative OHRQoL in skeletal Class III patients submitted to orthognathic surgery.

Materials and methods

This longitudinal study consisted of ninety-nine patients with skeletal Class III malocclusion who required orthognathic surgery. The Oral Health Impact Profile-14 (OHIP-14) is a questionnaire used to assess the OHRQoL with a 5‐point Likert‐type scale, covering seven domains related to physical and psychosocial factors. The questionnaire was applied in the preoperative and postoperative periods, and the difference scores were calculated to assess the OHRQoL after orthognathic surgery. The DNA was extracted from oral mucosa cells to evaluate genetic polymorphisms in ANKK1, DRD2, ESR1, and ESR2 through real-time PCR.

Results

There was an improvement in all OHRQoL domains following orthognathic surgery (p < 0.05). In the preoperative evaluation, women presented worse OHRQoL (p < 0.05) than men. There was no statistical difference between sex and the OHRQoL after surgery (p > 0.05). When evaluating the polymorphisms and preoperative OHIP-14 scores, CT genotype patients for rs1800497 (ANKK1) had a worse perception of the physical pain domain than CC genotype (p = 0.026), and CC genotype patients for rs1256049 (ESR2) had a worse perception of the functional limitation domain than CT genotype (p = 0.002). In the analysis between polymorphisms and postoperative and preoperative difference scores, CT genotype patients for rs1256049 (ESR2) had a greater improvement in the perception of the physical pain domain than the CC genotype (p = 0.031). In rs6275 and rs6276 (DRD2), patients with the CC genotype worsened the perception of the functional limitation domain than the TT genotype (p = 0.045), and AA genotype patients worsened the perception of the functional limitation domain than GG genotype (p = 0.048) after surgery, respectively. In addition, patients with the CT genotype for rs1800497 (ANKK1) had a greater improvement of OHRQoL perception in the total scale than the TT genotype (p = 0.018), and CT genotype patients had a greater improvement in the perception of function limitation domain than TT genotype (p = 0.017).

Conclusion

Women have a worse perception of OHRQoL in the preoperative period of orthognathic surgery. Furthermore, polymorphisms in the ANKK1, DRD2, and ESR2 genes could be involved with OHRQoL in the preoperative period and following orthognathic surgery.

Clinical relevance

The knowledge of the genetic background concerning OHRQoL in skeletal class III patients would aid in clinical practice to screen for associated genetic factors and prevent OHRQoL deterioration, especially after orthognathic surgery, considering that patients’ genetic profiles would soon be available.

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References

  1. Gava EC, Miguel JA, de Araújo AM, de Oliveira BH (2013) Psychometric properties of the Brazilian version of the Orthognathic Quality of Life Questionnaire. J Oral Maxillofac Surg 71:1762.e1761-1768. https://doi.org/10.1016/j.joms.2013.05.020

    Article  Google Scholar 

  2. Corso PFCdL, Oliveira FACd, Costa DJd, Kluppel LE, Rebellato NLB, Scariot R (2016) Evaluation of the impact of orthognathic surgery on quality of life. Braz Oral Res 30:S1806-83242016000100210. https://doi.org/10.1590/1807-3107BOR-2016.vol30.0004

    Article  PubMed  Google Scholar 

  3. Palomares NB, Celeste RK, Miguel JA (2016) Impact of orthosurgical treatment phases on oral health-related quality of life. Am J Orthod Dentofacial Orthop 149:171–181. https://doi.org/10.1016/j.ajodo.2015.07.032

    Article  PubMed  Google Scholar 

  4. Kilinc A, Ertas U (2015) An assessment of the quality of life of patients with class III deformities treated with orthognathic surgery. J Oral Maxillofac Surg 73:1394.e1391-1395. https://doi.org/10.1016/j.joms.2015.02.019

    Article  Google Scholar 

  5. Rezaei F, Masalehi H, Golshah A, Imani MM (2019) Oral health-related quality of life of patients with class III skeletal malocclusion before and after orthognathic surgery. BMC Oral Health 19:289. https://doi.org/10.1186/s12903-019-0989-9

    Article  PubMed  PubMed Central  Google Scholar 

  6. Baherimoghaddam T, Tabrizi R, Naseri N, Pouzesh A, Oshagh M, Torkan S (2016) Assessment of the changes in quality of life of patients with class II and III deformities during and after orthodontic-surgical treatment. Int J Oral Maxillofac Surg 45:476–485. https://doi.org/10.1016/j.ijom.2015.10.019

    Article  PubMed  Google Scholar 

  7. Bergamaschi IP, Cavalcante RC, Fanderuff M, Gerber JT, Petinati MFP, Sebastiani AM, da Costa DJ, Scariot R (2021) Orthognathic surgery in class II patients: a longitudinal study on quality of life, TMD, and psychological aspects. Clin Oral Investig 25:3801–3808. https://doi.org/10.1007/s00784-020-03709-3

    Article  PubMed  Google Scholar 

  8. Silva I, Cardemil C, Kashani H, Bazargani F, Tarnow P, Rasmusson L, Suska F (2016) Quality of life in patients undergoing orthognathic surgery - a two-centered Swedish study. J Craniomaxillofac Surg 44:973–978. https://doi.org/10.1016/j.jcms.2016.04.005

    Article  PubMed  Google Scholar 

  9. Sebastiani AM, Dos Santos KM, Cavalcante RC, Pivetta Petinati MF, Signorini L, Antunes LAA, Rebellato NLB, Küchler EC (2020) Scariot R (2020) Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery. Qual Life Res 29:3315–3323. https://doi.org/10.1007/s11136-020-02581-8

    Article  PubMed  Google Scholar 

  10. Meger MN, Fatturi AL, Gerber JT, Weiss SG, Rocha JS, Scariot R (2021) Wambier LM (2021) Impact of orthognathic surgery on quality of life of patients with dentofacial deformity: a systematic review and meta-analysis. Br J Oral Maxillofac Surg 59:265–271. https://doi.org/10.1016/j.bjoms.2020.08.014

    Article  PubMed  Google Scholar 

  11. Chew MT (2006) Spectrum and management of dentofacial deformities in a multiethnic Asian population. Angle Orthod 76:806–809. https://doi.org/10.1043/0003-3219(2006)076[0806:SAMODD]2.0.CO;2

    Article  PubMed  Google Scholar 

  12. Severt TR, Proffit WR (1997) The prevalence of facial asymmetry in the dentofacial deformities population at the University of North Carolina. Int J Adult Orthodon Orthognath Surg 12:171–176

    PubMed  Google Scholar 

  13. Kulczynski FZ, Andriola FO, Deon PH, Melo DADS (2018) Pagnoncelli RM (2018) Postural assessment in class III patients before orthognathic surgery. J Oral Maxillofac Surg 76:426–435. https://doi.org/10.1016/j.joms.2017.07.157

    Article  PubMed  Google Scholar 

  14. Jung MH (2016) Quality of life and self-esteem of female orthognathic surgery patients. J Oral Maxillofac Surg 74:1240.e1241-1247. https://doi.org/10.1016/j.joms.2016.01.046

    Article  Google Scholar 

  15. Slade GD (1997) Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol 25:284–290. https://doi.org/10.1111/j.1600-0528.1997.tb00941.x

    Article  PubMed  Google Scholar 

  16. Sprangers MA, Thong MS, Bartels M, Barsevick A, Ordoñana J, Shi Q, Wang XS, Klepstad P, Wierenga EA, Singh JA, Sloan JA, GeneQol Consortium (2014) Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update. Qual Life Res 23:1997–2013. https://doi.org/10.1007/s11136-014-0656-1

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zhang L, Hu L, Li X, Zhang J (2014) Chen B (2014) The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis. J Affect Disord 158:71–77. https://doi.org/10.1016/j.jad.2014.01.015

    Article  PubMed  Google Scholar 

  18. Savitz J, Hodgkinson CA, Martin-Soelch C, Shen PH, Szczepanik J, Nugent AC, Herscovitch P, Grace AA, Goldman D, Drevets WC (2013) DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. Int J Neuropsychopharmacol 16:2095–2101. https://doi.org/10.1017/S146114571300045X

    Article  PubMed  Google Scholar 

  19. Gabardo M, Zielak J, Tórtora G, Gerber J, Meger M, Rebellato N, Küchler E, Scariot R (2019) Impact of orthognathic surgery on quality of life: predisposing clinical and genetic factors. J Craniomaxillofac Surg 47:1285–1291. https://doi.org/10.1016/j.jcms.2019.05.001

    Article  PubMed  Google Scholar 

  20. Opmeer EM, Kortekaas R, Aleman A (2010) Depression and the role of genes involved in dopamine metabolism and signalling. Prog Neurobiol 92:112–133. https://doi.org/10.1016/j.pneurobio.2010.06.003

    Article  PubMed  Google Scholar 

  21. Kao CF, Fang YS, Zhao Z, Kuo PH (2011) Prioritization and evaluation of depression candidate genes by combining multidimensional data resources. PloS one 6:e18696. https://doi.org/10.1371/journal.pone.0018696

    Article  PubMed  PubMed Central  Google Scholar 

  22. Lawford BR, Young R, Noble EP, Kann B, Ritchie T (2006) The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. Eur Psychiatry 21:180–185. https://doi.org/10.1016/j.eurpsy.2005.01.006

    Article  PubMed  Google Scholar 

  23. Uetanabaro LC, Gerber JT, Dos Santos KM, Meger MN, da Costa DJ, Küchler EC, et al (2022) Prevalence and associated factors of myofascial pain in orthognathic patients with skeletal class II malocclusion. Oral and maxillofacial surgery

  24. Georgiou P, Zanos P, Jenne CE, Gould TD (2019) Sex-specific involvement of estrogen receptors in behavioral responses to stress and psychomotor activation. Front Psychiatry 10:81. https://doi.org/10.3389/fpsyt.2019.00081

    Article  PubMed  PubMed Central  Google Scholar 

  25. Scariot R, Tomaz CO, Calixto RD, Gerber JT, Pivetta Petinati MF, Cavalcante RC, Küchler EC, João da Costa D (2019) Association between gender, estrogen receptors genes and anxiety levels in patients undergoing orthognathic surgery. J Craniomaxillofac Surg 47:1300–1305. https://doi.org/10.1016/j.jcms.2019.05.003

    Article  PubMed  Google Scholar 

  26. Machado NCS, Gerber JT, Santos KM, Bergamaschi IP, Meger MN, Costa DJ, Küchler EC, Scariot R (2022) Association of estrogen receptor gene and oral health-related quality of life in dentofacial deformity patients. Braz Oral Res 36: In Press

  27. Little J, Higgins JP, Ioannidis JP et al (2009) STrengthening the REporting of Genetic Association Studies (STREGA)–an extension of the STROBE statement. Genet Epidemiol 33:581–598. https://doi.org/10.1002/gepi.20410

    Article  PubMed  Google Scholar 

  28. Guyer EC, Ellis EE 3rd, McNamara JA Jr, Behrents RG (1986) Components of class III malocclusion in juveniles and adolescents. Angle Orthod 56:7–30. https://doi.org/10.1043/0003-3219(1986)056%3c0007:COCIMI%3e2.0.CO;2

    Article  PubMed  Google Scholar 

  29. LAURIS, J. R. P. Sample calculation. Available in: http://calculoamostral.bauru.usp.br/calculoamostral/ta_ic_proporcao.php

  30. Trevilatto PC, Line SR (2000) Use of buccal epithelial cells for PCR amplification of large DNA fragments. J Forensic Odontostomatol 18:6–9

    PubMed  Google Scholar 

  31. Aidar M, Line SR (2007) A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J 18:148–152

    Article  PubMed  Google Scholar 

  32. Lee L, Connell C, Bloch W (1993) Allelic discrimination by nick-translation PCR with fluorogenic probes. Nucleic Acids Res 21:3761–3766. https://doi.org/10.1093/nar/21.16.3761

    Article  PubMed  PubMed Central  Google Scholar 

  33. Rusanen J, Lahti S, Tolvanen M, Pirttiniemi P (2010) Quality of life in patients with severe malocclusion before treatment. Eur J Orthod 32:43–48. https://doi.org/10.1093/ejo/cjp065

    Article  PubMed  Google Scholar 

  34. Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M (2000) Low dopamine D(2) receptor binding potential in social phobia. Am J Psychiatry 157:457–459. https://doi.org/10.1176/appi.ajp.157.3.457

    Article  PubMed  Google Scholar 

  35. Finan PH, Smith MT (2013) The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev 17:173–183. https://doi.org/10.1016/j.smrv.2012.03.003

    Article  PubMed  Google Scholar 

  36. Qadri YJ, Bortsov AV, Orrey DC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Mclean SA (2015) Genetic polymorphisms in the dopamine receptor 2 predict acute pain severity after motor vehicle collision. Clin J Pain 31:768–775. https://doi.org/10.1097/AJP.0000000000000167

    Article  PubMed  PubMed Central  Google Scholar 

  37. Chu CS, Chu CL, Liang CK, Lu T, Lin YT, Chou MY, Chow PC (2019) Association between polymorphisms in dopamine-related genes and orthopedic pain expression in a Chinese elderly population. Pain Pract 19:211–221. https://doi.org/10.1111/papr.12737

    Article  PubMed  Google Scholar 

  38. Hoofwijk DM, van Reij RR, Rutten BP, Kenis G, Buhre WF, Joosten EA (2016) Genetic polymorphisms and their association with the prevalence and severity of chronic postsurgical pain: a systematic review. Br J Anaesth 117:708–719. https://doi.org/10.1093/bja/aew378

    Article  PubMed  Google Scholar 

  39. Dawson A, Stensson N, Ghafouri B, Gerdle B, List T, Svensson P, Ernberg M (2016) Dopamine in plasma – a biomarker for myofascial TMD pain? J Headache Pain 17:65. https://doi.org/10.1186/s10194-016-0656-3

    Article  PubMed  PubMed Central  Google Scholar 

  40. Deng Y, Huang J, Zhang H, Zhu X, Gong Q (2018) Association of expression of DRD2 rs1800497 polymorphism with migraine risk in Han Chinese individuals. J Pain Res 11:763–769. https://doi.org/10.2147/JPR.S151350

    Article  PubMed  PubMed Central  Google Scholar 

  41. Ryan J, Scali J, Carrière I, Peres K, Rouaud O, Scarabin PY, Ritchie K, Ancelin ML (2011) Oestrogen receptor polymorphisms and late-life depression. Br J Psychiatry 199:126–131. https://doi.org/10.1192/bjp.bp.111.091751

    Article  PubMed  PubMed Central  Google Scholar 

  42. Küchler EC, Meger MN, Ayumi Omori M, Gerber JT, Carneiro Martins Neto E, Silva Machado NCD, Cavalcante RC, Teixeira LR, Stuani MB, Nelson Filho P, da Costa DJ, Souza JF, Brancher JA, León JE, Scariot R (2020) Association between oestrogen receptors and female temporomandibular disorders. Acta Odontol Scand 78:181–188. https://doi.org/10.1080/00016357.2019.1675904

    Article  PubMed  Google Scholar 

  43. Chen J, Kamiya Y, Polur I, Xu M, Choi T, Kalajzic Z, Drissi H, Wadhwa S (2014) Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth. Osteoarthr Cartil 22:1861–1868. https://doi.org/10.1016/j.joca.2014.07.003

    Article  Google Scholar 

  44. Nicot R, Vieira AR, Raoul G, Delmotte C, Duhamel A, Ferri J, Sciote JJ (2016) ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical treatment response in dentofacial deformities. J Craniomaxillofac Surg 44:1226–1237. https://doi.org/10.1016/j.jcms.2016.07.010

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

This work was supported by the São Paulo Research Foundation (FAPESP) (funding number: 2015/06866–5) and individual scholarships (FAPESP and CAPES).

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Authors and Affiliations

  1. School of Health Sciences, Positivo University, 5300 Professor Pedro Viriato Parigot de Souza Street, Curitiba, PR, 81280-330, Brazil

    Michelle Nascimento Meger & Jennifer Tsi Gerber

  2. Department of Stomatology, School of Dentistry, Federal University of Parana, 632 Prefeito Lothario Meissner Avenue, Curitiba, PR, 80210-170, Brazil

    Willian Martins Azeredo, Aline Monise Sebastiani, Leandro Eduardo Klüppel & Rafaela Scariot

  3. Latin American Institute of Dental Research and Education, 656 Jacarezinho Street, Curitiba, PR, 80710-150, Brazil

    Tatiana Miranda Deliberador

  4. Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n – Campus da USP, Ribeirão Preto, 14040-904, Brazil

    Erika Calvano Küchler

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  1. Michelle Nascimento Meger
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Contributions

M.N.M contributed to formal analyses, investigation, data curation, and writing original draft; J.T.G. contributed to the investigation, data curation, reviewing, and editing of the manuscript; W.M.A. contributed to the investigation and data curation; A.M.S. contributed to conceptualization, investigation, and methodology; T.M.D. contributed to the investigation, project administration, and reviewing the manuscript; E.C.K contributed to resources, funding acquisition, laboratory analysis, and reviewing the manuscript; L.E.K. contributed to the investigation, project administration, and reviewing the manuscript; R.S. contributed to the conceptualization, investigation, methodology, project administration, funding acquisition, and reviewing the manuscript. All the authors gave final approval and agreed to account for all aspects of the work.

Corresponding author

Correspondence to Rafaela Scariot.

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Meger, M.N., Gerber, J.T., Azeredo, W.M. et al. Genetic polymorphisms are involved in oral health–related quality of life in skeletal class III patients submitted to orthognathic surgery. Clin Oral Invest 27, 1409–1421 (2023). https://doi.org/10.1007/s00784-023-04925-3

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