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Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery

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Abstract

Purpose

To assess oral health-related quality of life (OHRQoL) in patients requiring orthognathic surgery, and evaluate if depression, temporomandibular disorders (TMD), and genetic polymorphisms in interleukin-6 (IL6) influence their OHRQoL.

Methods

A total of 132 individuals included in three different groups. Two groups were composed by patients with dentofacial deformity (DFD) Class II (n = 44) or Class III (n = 44) malocclusions, requiring orthognathic surgery. The control group (n = 44) included individuals without DFD. Patients from all groups were evaluated in preoperative appointments to assessOHRQoL, TMD, and genetic polymorphisms in IL6. OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). TMD and depression were assessed using Research Diagnostic Criteria for Temporomandibular Disorders protocol. The genetic polymorphisms rs1800795 and rs1800796 in IL6 were assessed through genomic DNA using real-time polymerase chain reaction.

Results

OHIP-14 scores were increased in patients with depression, myofascial pain, and inflammatory temporomandibular joint alterations in the right side, regardless of sex and DFD group. Individual homozygous CC in rs1800795 had increased values in domains “social disability” and “handicap” of the OHIP-14 compared with those who were homozygous GG. Individual heterozygous CG in the rs1800796 demonstrated increased values in domain “psychological discomfort” compared with those homozygous for CC and GG.

Conclusion

In individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms in IL6 contribute to negative impact on OHRQoL. These physical and emotional conditions, together with biological pathways, should receive more attention in treatment plans, in order to improve the patients’ quality of life.

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Acknowledgement

This work was supported by individual scholarships (FAPESP – Fundação de Amparo à Pesquisa do Estado de São Paulo-2016/08149-1 and CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

Funding

The work was supported by individual scholarships (FAPESP – Fundação de Amparo à Pesquisa do Estado de São Paulo- 2016/08149-1 and CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

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Authors and Affiliations

  1. School of Health and Biological Sciences, Positivo University, Curitiba, Brazil

    Aline Monise Sebastiani, Katheleen Miranda dos Santos, Maria Fernanda Pivetta Petinati, Luciana Signorini, Erika Calvano Küchler & Rafaela Scariot

  2. Department of Stomatology, Federal University of Parana, Curitiba, Brazil

    Aline Monise Sebastiani, Rafael Correia Cavalcante, Nelson Luis Barbosa Rebellato & Rafaela Scariot

  3. Department of Specific Training, Dentistry, Nova Friburgo Insitute, Fluminense Federal University, Rio de Janeiro, Brazil

    Livia Azeredo Alves Antunes

  4. Department of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo School of dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    Erika Calvano Küchler

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  1. Aline Monise Sebastiani
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  2. Katheleen Miranda dos Santos
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Contributions

All authors contributed to the study conception. The study design was performed by [RS] and [AMS]. Material preparation and data collection were performed by [KMS], [RCC], and [MFP]. Data collection was supervision by [NLBR] and [LS]. Data analyses were performed by [ECK], [RS], and [AMS]. The first draft of the manuscript was written by [AMS] and [RS], the review and editing were performed by [LAAA] and [ECK]. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. All authors effectively contributed to this work and are familiar with its contents; and assume the responsibility for its contents.

Corresponding author

Correspondence to Aline Monise Sebastiani.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in study were in accordance with the ethical standards of the institutional research committee (Positivo University and Universidade Federal do Paraná: CAEE 69240817.7.0000.0093 and CAAE 69725317.5.0000.0102) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sebastiani, A.M., dos Santos, K.M., Cavalcante, R.C. et al. Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery. Qual Life Res 29, 3315–3323 (2020). https://doi.org/10.1007/s11136-020-02581-8

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