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Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study

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Abstract

Objectives

Oral lichen planus (OLP) is a chronic immune-mediated disease that affects the oral cavity. Topical steroids are considered the treatment of choice for painful lesions of OLP. The aim of this split-mouth study was to compare the efficacy of platelet-rich fibrin (PRF) and triamcinolone acetonide (TA) injective therapies in patients with symptomatic OLP.

Materials and methods

Participants with symptomatic OLP were recruited in the Academic Hospital of Magna Graecia University of Catanzaro, Italy. Once a week for a month, patients randomly received a 0.5-mL TA injection in one buccal mucosa and 1-mL PRF injection in the opposite side. The measured outcomes were reduction of the lesions area and symptomatology modifications using visual analogue scale (VAS) score

Results

Four weeks after the last injections, an average reduction of 59.8% in the lesion extension and an average reduction of 47.6% in the VAS score for PRF-treated sites were observed; the same variation for TA-treated sites was respectively of 59.2% and 40%. There were no statistically significant differences between the two groups.

Conclusions

PRF was effective in reducing OLP lesions extension and symptomatology, and it seems to be as effective as TA. Additional data should be collected with a larger sample size, at a longer follow-up and on the PRF lowest effective dose.

Clinical Relevance

Current treatment options for OLP are limited. The study proved benefits of PRF injections in management of painful lesions of OLP comparable with TA.

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Authors and Affiliations

  1. School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy

    Francesco Bennardo, Francesco Liborio, Selene Barone, Alessandro Antonelli, Caterina Buffone, Leonzio Fortunato & Amerigo Giudice

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  1. Francesco Bennardo
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  2. Francesco Liborio
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  3. Selene Barone
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  4. Alessandro Antonelli
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  5. Caterina Buffone
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  6. Leonzio Fortunato
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  7. Amerigo Giudice
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Contributions

Conceptualization: Francesco Bennardo, Amerigo Giudice; methodology: Francesco Bennardo, Francesco Liborio; formal analysis and investigation: Francesco Bennardo, Francesco Liborio, Alessandro Antonelli, Caterina Buffone; writing—original draft preparation: Francesco Bennardo, Francesco Liborio; writing—review and editing: Selene Barone, Caterina Buffone, Amerigo Giudice; supervision: Leonzio Fortunato, Amerigo Giudice.

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Correspondence to Francesco Bennardo.

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Research involving human participants and/or animals

The ethical approval was obtained by the Ethical Review Board of Central Calabria (Prot. No. 23/2019).

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All patients enrolled for the study signed an informed consent.

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Bennardo, F., Liborio, F., Barone, S. et al. Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study. Clin Oral Invest 25, 3747–3755 (2021). https://doi.org/10.1007/s00784-020-03702-w

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