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How to intervene in the caries process in adults: proximal and secondary caries? An EFCD-ORCA-DGZ expert Delphi consensus statement



To provide consensus recommendations on how to intervene in the caries process in adults, specifically proximal and secondary carious lesions.


Based on two systematic reviews, a consensus conference and followed by an e-Delphi consensus process were held with EFCD/ORCA/DGZ delegates.


Managing an individual’s caries risk using non-invasive means (oral hygiene measures including flossing/interdental brushes, fluoride application) is recommended, as both proximal and secondary carious lesions may be prevented or their activity reduced. For proximal lesions, only cavitated lesions (confirmed by visual-tactile, or radiographically extending into the middle/inner dentine third) should be treated invasively/restoratively. Non-cavitated lesions may be successfully arrested using non-invasive measures in low-risk individuals or if radiographically confined to the enamel. In high-risk individuals or if radiographically extended into dentine, for these lesions, additional micro-invasive (lesion sealing and infiltration) treatment should be considered. For restoring proximal lesions, adhesive direct restorations allow minimally invasive, tooth-preserving preparations. Amalgams come with a lower risk of secondary lesions and may be preferable in more clinically complex scenarios, dependent on specific national guidelines. In structurally compromised (especially endodontically treated) teeth, indirect cuspal coverage restorations may be indicated. Detection methods for secondary lesions should be tailored according to the individual’s caries risk. Avoiding false positive detection and over-treatment is a priority. Bitewing radiographs should be combined with visual-tactile assessment to confirm secondary caries detections. Review/refurbishing/resealing/repairing instead of replacing partially defective restorations should be considered for managing secondary caries, if possible.


An individualized and lesion-specific approach is recommended for intervening in the caries process in adults.

Clinical significance

Dental clinicians have an increasing number of interventions available for the management of dental caries. Many of them are grounded in the growing understanding of the disease. The best evidence, patients’ expectations, clinicians’ expertise, and the individual clinical scenario all need to be considered during the decision-making process.

The caries process in adults: proximal and secondary carious lesions

Much of caries research has been based in the pediatric domain as caries has been regarded classically as predominantly a childhood disease. This was grounded in the past epidemiologic evidence, which did not report significant caries increment in adults. This was due mainly to the fact that restored surfaces were not recorded as being able to become “carious” again in these standard epidemiologic assessments. However, as demonstrated by birth cohort studies, the caries increment seems to remain fairly stable from childhood into adult life if accounting for the tooth surfaces at risk [1, 2]. Caries is therefore as much a disease of adults and older adults as it is of children.

Carious lesions in adults occur primarily on proximal surfaces or are associated with existing restorations (secondary caries) in permanent teeth. The reasons for proximal and secondary caries being a major problem in adults are many.

(1) Occlusal lesions are either successfully prevented long-term by pit-and-fissure sealants [3], or occlusal surfaces are restored during childhood given that active occlusal lesions occur early after the eruption of the tooth and progress relatively fast. In adults, incidence and progression rates of occlusal lesions reduce markedly [4].

(2) Exposed root surfaces are often not evident in this age group. Only later and in conjunction with reduced periodontal support with or without underlying periodontitis [5], root surface carious lesions become more common [3, 10].

(3) On proximal surfaces of permanent teeth, lesion development is usually relatively slow. In low caries risk/susceptible patients, several years or even decades may pass until a radiographically detectable lesion occurs [4]. Hence, in children, proximal lesions of permanent teeth are not common as they do not usually have enough time to develop; one exception being the mesial surface of the first permanent molars whilst in contact with the distal surface of the second primary molar which, at the earliest stages, are under risk during a specifically vulnerable time period [6]. Over time and manifesting in adulthood, though, proximal lesions are found developing and progressing frequently, even in well-maintained/motivated populations in high-income countries [7].

(4) Secondary carious lesions are, by definition, associated with existing restorations, with proximally extended restorations showing an increased risk compared with occlusally limited restorations. They occur largely later during adulthood, especially as many younger adults today have fewer restorations which can suffer from secondary lesions [8]. The nature of secondary lesions will be discussed further below, building on the compiled evidence of the systematic reviews underlying this consensus statement.

Materials and methods

The present consensus statement is part of a series established jointly by the European Federation of Conservative Dentistry (EFCD) and the European Organisation of Caries Research (ORCA). Both organizations strive to promote research and evidence-based practice in the field of cariology and conservative dentistry. Under the tenets of both organizations and following a pilot workshop and consensus process conducted in 2018 on “When to intervene in the caries process?” [9], a consensus process on “How to intervene in the caries process” was initiated in 2019. Due to the high complexity of the question of how to treat dental caries, the topic was divided into three age groups of patients: children and adolescents, adults, and older adults. The present statement specifically deals with the caries process in adults; it focuses on proximal and secondary carious lesions in permanent teeth, two common manifestations of the caries process in this age group. Two other statements focus on caries in children, specifically early childhood caries, primary molar caries and occlusal caries in permanent molars; and older adults, specifically root caries.

The workshop participants had been selected and invited by the boards of ORCA, EFCD, and German Society of Conservative Dentistry (DGZ), achieving a balanced representation of international clinical and academic experts in the disciplines of cariology, restorative dentistry, pediatric dentistry, and gerodontology. Overall, 25 delegates participated in the process. The costs of the workshop were covered solely by the participating dental associations. To summarize the current scientific knowledge, selected members of the three associations had been asked before to prepare systematic literature reviews regarding the treatment of most prevalent caries forms in the three age groups. The reviews were published in Caries Research and Clinical Oral Investigations.

Based on these reviews as well as other literature from structured consensus statements, recommendations were drafted by the group chairs (FS, AB) and sent to the delegates prior to the meeting. At the meeting, each statement was discussed extensively and modified until consensus was reached. The strength of each recommendation was evaluated by the group as being “strong,” “moderate,” or “weak,” based on the scientific evidence supporting the statement. Recommendations supported by unequivocal evidence (e.g., several high-quality randomized controlled trials) were as evaluated as “strong.” Recommendations based on moderate evidence (e.g., high-quality clinical studies with similar outcomes) were evaluated as “moderate.” Finally, recommendations based on expert opinion only or on low-quality studies or studies with contradicting outcomes were evaluated as “weak.”

The voting on the statement was graded from 1 (completely disagree) to 10 (completely agree) and performed using an online platform (Surveyjet, Calibrum, St. George, USA). At least 70% of the votes over 7 were considered as acceptance of the statement by the group, and in addition, the median of all votes was calculated. An additional field for free-text comments was also available to illustrate the reasoning for a certain decision or proposal for future modifications.

The aim of the present statement is to compile the best available evidence, appraise it, and use it to derive clinically applicable, consented recommendations on how to intervene in the caries process in adults. It is specifically developed to support decision-making in pragmatic clinical practice and while all recommendations are consented (see below); their scientific evidence base is often limited, as indicated. Hence, this statement also highlights research gaps for potential future investigation. Before presenting the findings of the systematic reviews and the resulting recommendations, a brief overview of caries management in adults including some detail with respect to the types of carious lesions occurring more commonly in the adult age group will be discussed.


How to intervene in proximal lesions

A recent consensus statement [9] established guidelines on when to intervene on proximal lesions. It was agreed that for non-cavitated lesions, minimally invasive (restorative) strategies should be avoided, and non- or micro-invasive strategies are preferable. Non-invasive strategies do not remove dental hard tissue and involve, for example, topical fluorides and other chemical agents for controlling mineral balance, biofilm control measures, and dietary control. Micro-invasive strategies remove the dental hard tissue surface at the micron level, usually during an etching step, such as used in sealing or infiltration techniques. Minimally invasive operative strategies remove a limited amount of gross dental hard tissue, through the use of hand excavators, rotary instruments, or other devices. In most cases, this process is associated with the subsequent placement of restorations. The specific types of non- and micro-invasive strategies have been laid out in more detail in the systematic review underlying this consensus statement, together with the evidence supporting them (see Table 1 and below). Cavitation status should be assessed using visual and/or tactile methods, and/or the radiographic lesion depth as a proxy, with cavitation being unlikely in lesions radiographically confined to enamel, likely in those clearly entering the middle third of dentine, and variable for lesions around the enamel-dentine junction/outer third of the dentine.

Table 1 Non- and micro-invasive strategies for managing proximal lesions and the associated evidence base

The systematic review [10] identified mainly studies combining oral hygiene measures and fluoride application for managing proximal lesions, either as part of long-term cohort studies or as control arm of randomized trials comparing non- and micro-invasive strategies for managing proximal lesions. Overall, in most low caries risk/susceptible populations, lesion progression was slow, taking several years. Progression was more rapid in lesions extending radiographically into dentine than in enamel alone, in molars rather than premolars, and in adolescents rather than adults. Notably, in highly caries susceptible individuals, lesion progression can be faster, with non-cavitated lesions progressing to cavitated dentine lesions over a 1–2-year period. Generally, non-invasive measures depend on the potential for patients’ behavioral modification and adherence which is not often considered in such studies [57]. Overall, the evidence supporting non-invasive management of proximal lesions as a therapy vs. doing nothing was graded weak. However, as non-invasive measures also aim to modify a patient’s caries risk/susceptibility, they are relevant clinically as part of fundamental disease prevention.

For micro-invasive management of proximal lesions, a larger and more robust body of evidence was available, with a number of randomized trials assessing micro-invasive treatment combined with non-invasive measures vs. non-invasive management alone. The studies found that micro-invasive treatment combined with non-invasive measures arrests non-cavitated enamel and initial dentine lesions (limited to the outer third of dentine based on radiograph and clinically non-cavitated) and is significantly more effective than non-invasive management alone. However, it remained unclear which micro-invasive technique offered the greatest benefit. There was some evidence that both sealing and resin infiltration can arrest enamel-limited lesions and those around the enamel-dentine junction, while only infiltration techniques were effective for lesions involving the dentine. Overall, the evidence supporting micro-invasive treatment combined with non-invasive measures of proximal lesions was graded as moderate.

For the minimally invasive restorative/operative management of proximal lesions, a larger number of studies were available. Mean annual failure rates varied between 1.2 and 3.8% (after weighting for sample size). When restricting to only proximal restorations, conventional resin composites showed a significantly higher risk of failure than amalgams; all other materials did not perform significantly differently than conventional resin composites. Notably, though, studies were conducted at different times, with different materials and different operator experience, which makes comparisons difficult. Overall, the evidence was graded as weak. Amalgams appear to show a lower risk of failure in proximal cavities than most other materials. In light of many patients wishing to receive tooth-colored restorations, but also because the aim of minimally invasive tooth tissue preservation, by biologically oriented lesion preparation, as well as considering the current global phase-down of dental amalgam associated with the Minamata agreement [11], adhesive bio-interactive restorations are common in many countries. For extensive defects, especially in endodontically treated teeth, indirect restorations may also be considered on an individualized basis.

Based on these findings for proximal lesions, the consensus group developed the following recommendations:

  1. 1.

    Overall, the management of proximal lesions should be provided under the tenet of a preventively oriented approach (dietary advice, oral hygiene motivation). Managing a patient’s caries risk/susceptibility will also help support managing specific proximal lesions and assist in the prevention of new lesions on unaffected surfaces.

  2. 2.

    For non-cavitated lesions:

    1. a.

      Non-invasive measures (e.g., interdental cleaning, topical fluoride application) could be applied to arrest proximal lesions. This may be sufficient for lesion arrest in low caries risk/susceptible individuals or for lesions radiographically confined to enamel (weak recommendation, agreement 88%, median: 10)

    2. b.

      In high-risk/susceptible individuals or for lesions extending radiographically into dentine, micro-invasive strategies should be considered additionally (moderate recommendation, agreement 83%, median: 10).

    3. c.

      The decision between sealing and resin infiltration should be guided by individual considerations, including applicability, clinical experience, or costs (moderate recommendation, agreement 88%, median: 10).

  3. 3.

    For cavitated lesions, restorative strategies will often be needed. For restoring proximal lesions, adhesive direct restorations allow minimally invasive, tooth-preserving preparations, are tooth-colored, and hence are already the material of choice in many cases. Amalgams, however, come with a lower risk of secondary lesions and since their placement is less technique-sensitive, they may be preferred in more clinically complex scenarios, dependent on specific national guidelines. According to legal regulations, the use of amalgam may be restricted in some countries or populations, now and in the future (weak recommendation, agreement 84%, median: 10).

  4. 4.

    In structurally compromised teeth, especially when endodontically treated, indirect cuspal coverage restorations may be indicated (weak recommendation, agreement 92%, median: 10).

How to intervene in secondary lesions

Secondary lesions may be primary carious lesions associated with existing restorations, as a result of the caries process not having been sufficiently addressed on a patient level [12,13,14], or may be caused by significant margin defects (interfacial gaps, ditches, etc.), allowing acidic by-products or a dysbiotic biofilm to enter the interface between the restoration and the tooth structure. Marginal gaps may be the result of imperfect initial placement of the restoration/management of the tooth surface [15], but also hydrolytic degradation of the hybrid layer of adhesive restorations [16, 17]. In any case, secondary lesions are found more often in high caries risk/susceptible patients [18, 19], at the gingival margin of restorations [20, 21], and in posterior teeth [22].

The second review underlying this consensus statement assessed a number of aspects related to secondary carious lesions:

(1) Can secondary lesions be managed using specific restorative techniques or materials?

(2) How can secondary lesions be detected, allowing their adequate management?

(3) If/when detected, which management strategy can be recommended?

Regarding the risk of secondary carious lesions next to restorations placed using different adhesive strategies and restorative materials, the review yielded only a few robust findings [23]. Overall, amalgams appear to be associated with a lower risk of secondary caries [24], which is in agreement with amalgams showing an overall lower risk of failure in most cavities (see above). Again, however, many dentists will be interested in knowing which non-amalgam materials are least prone to secondary lesions. For these materials (different resin composite types, but also resin-modified or conventional glass-ionomer cement or poly-acid modified resin composites/compomers), only very few differences emerged. Overall, patient- and operator-level factors seem to be decisive in controlling secondary carious lesions, while adhesive strategies and/or restorative materials may play a lesser role. This conclusion, however, is limited by the short follow-up periods, limited sample sizes, and the potential of low caries risk/susceptibility individuals enrolled in most trials.

Early detection of secondary lesions may allow the application of less invasive treatment options like surface refurbishment, re-sealing, or repair instead of complete restoration removal and replacement. A variety of early detection methods for secondary carious lesions are available, including visual, tactile, radiographic, laser fluorescence, and quantitative light-induced fluorescence assessments. These were assessed in a recent review [25], which found that visual, radiographic, and laser fluorescence detection had similar sensitivities and specificities (abilities to detect carious and sound surfaces, respectively), while tactile assessment and light-induced fluorescence are not as useful at present, at least not if used in isolation. There is further data demonstrating that in most low caries risk populations, avoiding false-positive readings and ultimate over-detection and treatment should be prioritized, as secondary lesions progress slowly (see above) and missed lesions may be detected at the next recall consultation [26]. Overall, it seems advisable to combine bitewing radiography (allowing the detection of clinically inaccessible lesions) with visual-tactile assessment (allowing confirmation of findings). If detected as suspect, but not treated, lesions should be monitored regularly. Moreover, dentists should consider to refurbish, reseal, or repair partially defective restorations if possible, as this allows the preservation of tooth structure and reduces the risk of subsequent treatment-related complications [27]. The evidence quality supporting the decision between refurbishment/reseal/repair vs. replacement, however, was found to be weak. Despite the obvious advantages of this minimally invasive approach (reduced tissue removal, reduced harm/pulp damage, lifetime of existing tooth-restoration complex is prolonged), there may be some other factors to consider (possibly higher long-term costs, careful case selection is required). Overall, the decision will need to consider the specific clinical situation (is repair even possible?), the patient’s wishes, and the dentist’s experience and expertise with different treatments.

Based on these findings for secondary carious lesions, the consensus group developed the following recommendations:

  1. 1.

    By managing a patient’s overall caries risk/susceptibility, the risk for secondary lesion occurrence is also managed to a certain extent (weak recommendation, agreement 87%, median: 10).

  2. 2.

    Detection methods for secondary lesions should be tailored according to patients’ caries risk/susceptibility. Especially in low-risk patients, false-positive detection, and subsequent over-treatment should be avoided. This may be achieved by combining bitewing radiography and visual-tactile assessment/confirmation when screening for secondary lesions (weak recommendation, agreement 88%, median: 10).

  3. 3.

    When managing detected secondary lesions, dentists should adopt the minimally invasive approaches of refurbishment/reseal/repair over replacement of restorations, on a case-by-case basis (weak recommendation, agreement 100%, median: 10).


The management of carious lesions and caries experience is a daily routine for dentists worldwide. In adults, two specific lesion types are managed frequently: proximal and secondary lesions. The present consensus statement provides agreed recommendations for managing these lesions. Dental clinicians should consider these recommendations in their daily decision-making and apply them depending on the patients’ wishes, the individual clinical needs, and their experience and expertise.


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Funding statement

This study was supported by EFCD, ORCA, and DGZ.


Open Access funding provided by Projekt DEAL.

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The study was conceived by FS, CHS, SP, and AB. FS and AB wrote the manuscript. All authors read and approved the manuscript.

Corresponding author

Correspondence to Falk Schwendicke.

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Competing interests

AB received support for a researcher-led SR of sugar-free gum by Mars Wrigley. PB received an honorarium for consultancy on product development regarding future caries treatments in medically compromised adults from Mayser Pharma. LB received support for research protocols regarding dental adhesives from 3 M ESPE, Ivoclar Vivadent, Dentsply Sirona, VOCO, Heraeus Kulzer, Kuraray Noritake, Ultradent, and Pulpdent and material samples for this research from 3 M ESPE, Ivoclar Vivadent, Dentsply Sirona, VOCO, Heraeus Kulzer, Kuraray Noritake, Ultradent, Sweden&Martina, DMG, and Pulpdent. RAG received dental materials from DMG and from 3 M Oral Care to support some of the research cited in this paper. DJM received support for conference lecturing and attendance by dental manufacturing companies DMG, GC Corporation, and SDI. NO received financial support for a practice-based research network from Kuraray Europe. SP received royalties (Charité-hold patents on caries infiltration) from DMG and honorarium from GSK, CP GABA, and DMG. FS received an honorarium for consultancy on product development regarding future caries treatments, study support on radiopaque tagging of caries lesions, restoring teeth with selective caries excavation, for organizing IADR Symposia on caries treatment from DMG. CHS received research and travel support from SDI regarding the use of silver diammine fluoride. AFZ received an honorarium for consultancy on product development regarding future caries treatments from Colgate, GreenMark, and Calcivis; research support from Colgate, NIDCR, Greenmark, Delta Dental, and Calcivis; non-monetary support (e.g., equipment, facilities, research assistants, paid travel to meetings) for an IADR Symposia on caries detection by Calcivis. DZ received an honorarium for consultancy from Colgate Palmolive, Procter & Gamble, Greenmark Biomedical Inc., GlaxoSmithKline, and Johnson & Johnson, and research support from Novatis Pharmaceuticals, Johnson & Johnson, Univerlever, Hello Products, and Church and Dwight.

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Schwendicke, F., Splieth, C.H., Bottenberg, P. et al. How to intervene in the caries process in adults: proximal and secondary caries? An EFCD-ORCA-DGZ expert Delphi consensus statement. Clin Oral Invest 24, 3315–3321 (2020).

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  • Caries
  • Consensus
  • Decision-making
  • Fluoride
  • Infiltration
  • Recommendations
  • Restorations
  • Sealing