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The relationship between implant stability and bone health markers in post-menopausal women with bisphosphonate exposure

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Abstract

Objectives

The authors assessed the relationship between implant stability and bone turnover markers in patients with and without a history of bisphosphonate (BP) exposure for treatment of osteopenia/osteoporosis.

Materials and methods

One dental implant site was evaluated in 58 post-menopausal women with a spectrum of bone health in a "best practice" prospective cohort study. Each site had a previous or simultaneous bone augmentation procedure. BP exposure at enrollment was categorized as "never" or "past/current" exposure. Implant stability was assessed by resonance frequency analysis (RFA ISQ) at surgery and 8 weeks post-implant. Bone turnover markers, C-telopeptide collagen crosslinks (sCTX) and procollagen −1 N-terminal telopeptide (P1NP), were measured pre-treatment, 1, and 8 weeks following implant surgery.

Results

Mean age was 62.4 ± 6.8 years; 66 % were osteopenic/osteoporotic. Average RFA ISQ at placement for all participants was 63.5 ± 11.3, at 8 weeks post-surgery 74.2 ± 9.4 (p < 0.01). Among "past/current" BP users, there was a significant negative correlation between RFA ISQ values at 8 weeks post-implant placement and sCTX and P1NP values at 1 week (ρ = −.65 and ρ = −.55, respectively; p < 0.01) and 8 weeks (ρ = −.64 and ρ = −.52, respectively; p < 0.05).

Conclusion

RFA ISQ values increased between implant placement and 8 weeks post-surgery demonstrating successful osseointegration. Lower bone turnover was associated with better implant stability among patients with a history of BP exposure.

Clinical relevance

Further investigation of the relationship between BP exposure and implant stability is warranted in a larger population, as results may strongly impact on clinical practice decisions.

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Acknowledgments

We would like to thank our GCRC at the University of Connecticut Health Center, Institut Straumann, Basel, Switzerland for supplying implants and prosthetic components and NIH for their support for this work. This work was supported by an NIH grant, NIDCR R01DE017873-05, and our institutional CRC grant #M01RR006192.

Conflict of interest

David Shafer D.M.D.—Novartis consultant, member of their Adjudication Committee for studies involving risks of osteonecrosis of the jaws.

David Pendrys D.D.S. Ph.D and Martin Freilich D.D.S. received research support; Corporate Sponsored Research Program, 7/06–6/10; Institute Straumann, Basel, Switzerland; title: “Implant guided bone growth mediated by local delivery of osteogenic agents.” This grant supports research of new implant systems to regenerate alveolar bone growth. Roles: DP was a co-investigator and MF was a PI.

All other authors declare no conflict of interest.

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Authors and Affiliations

  1. University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-5456, USA

    Pamela Taxel, Denise Ortiz, David Shafer, David Pendrys, Susan Reisine & Martin Freilich

  2. Department of Oral Health and Diagnostic Sciences, Division of Oral Maxilofacial Radiology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Kandasamy Rengasamy

Authors
  1. Pamela Taxel
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  2. Denise Ortiz
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  3. David Shafer
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  4. David Pendrys
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  5. Susan Reisine
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  6. Kandasamy Rengasamy
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  7. Martin Freilich
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Corresponding author

Correspondence to Pamela Taxel.

Additional information

This work was presented as an oral presentation at International Association for Dental Research (Oral) March 2011, San Diego, CA, USA.

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Taxel, P., Ortiz, D., Shafer, D. et al. The relationship between implant stability and bone health markers in post-menopausal women with bisphosphonate exposure. Clin Oral Invest 18, 49–57 (2014). https://doi.org/10.1007/s00784-013-0951-1

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  • DOI: https://doi.org/10.1007/s00784-013-0951-1

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