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Development of a new certified reference material of tinidazole for quality and safety of agro-products

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Abstracts

Two independent approaches involving mass balance (MB) method and quantitative nuclear magnetic resonance (qNMR) technique were employed to measure the purity of a new certified reference material (CRM) of tinidazole. The mass fraction of pure tinidazole CRM was assigned to be 99.7 % with an expanded uncertainty of 0.6 % (k = 2). Sample preparation, qualitative analysis, certifying methods optimization, characterization, homogeneity testing, stability monitoring, and uncertainty evaluation were systemically and comprehensively studied in development of tinidazole CRM. The results indicate that the CRM is homogenous and stable at 4 °C for at least 6 months which satisfy the requirements of CRM. The new CRM (GBW(E)090756) can be applicable to instrument calibration and analytical method validation, especially for assurance of accuracy result of tinidazole determination in the program of nationwide routine monitoring and risk assessment for agro-products by Ministry of Agriculture (MOA) in China.

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Acknowledgments

The authors thank the Chinese Academy of Agricultural Sciences (Innovation Workshop Project) and the Ministry of Agriculture of the P. R. China (Special Fund for Agro-scientific Research) for the financial support.

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Authors and Affiliations

  1. Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China

    Mengrui Yang, Min Wang, Jian Zhou, Yinqing Song & Tongtong Wang

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  1. Mengrui Yang
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  2. Min Wang
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  3. Jian Zhou
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  4. Yinqing Song
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  5. Tongtong Wang
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Correspondence to Min Wang.

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Yang, M., Wang, M., Zhou, J. et al. Development of a new certified reference material of tinidazole for quality and safety of agro-products. Accred Qual Assur 21, 341–349 (2016). https://doi.org/10.1007/s00769-016-1221-0

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  • DOI: https://doi.org/10.1007/s00769-016-1221-0

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