Skip to main content
SpringerLink
Log in

Do proficiency tests always verify laboratories’ performance? The case of FAPAS PT 0270

  • Practioner's Report
  • Published:
Accreditation and Quality Assurance Aims and scope Submit manuscript

Abstract

In this paper, the case of FAPAS PT 0270 “Doramectin and Oxfendazole in Sheep Liver” is discussed. During evaluation of the data received from participants (determination of total, oxidised oxfendazole residue and calculation of the sum of oxfendazole and oxfendazole sulfone residues), significant differences were observed between the results obtained by use of two analytical approaches. This phenomenon can be explained by the route of oxfendazole metabolism, which results in the presence of fenbendazole in the sample. This was not predicted by the provider; consequently, not all the necessary tests on the material were conducted. Due to the high uncertainty of the z-scores in this test, the results of the PT cannot be used for purposes of evaluation, and the benefits of participation in PT 0270 are questionable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. ISO 17025:2005. General requirements for the competence of calibration and testing laboratories

  2. FAPAS® Proficiency Test 0270 Doramectin and oxfendazole in sheep liver November–December 2005. Report, 2006

  3. Food Analysis Performance Assessment Scheme (FAPAS®): protocol for the organisation and analysis of data, 6th edn. 2002

  4. Thompson M, Wood R (1993) J AOAC Int 76:929–940

    Google Scholar 

  5. Oxfendazole (Extrapolation to all ruminants). Summary report (4). EMEA/MRL/888/03-FINAL

  6. Danaher M, O’Keeffe M, Glennon JD (2003) Anal Chim Acta 483:313–324. doi:10.1016/S0003–2670(02)01532–5

    Article  CAS  Google Scholar 

  7. Dowling G, Cantwell H, O’Keeffe M, Smyth MR (2005) Anal Chim Acta 529:285–292. doi:22572410.1016/j.aca.2004.07.064

    Article  CAS  Google Scholar 

  8. Stubbings G, Tarbin J, Cooper A, Sharman M, Bigwood T, Robb P (2005) Anal Chim Acta 547:262–268. doi:10.1016/j.aca.2005.05.001

    Article  CAS  Google Scholar 

  9. Szprengier-Juszkiewicz T (1997) Medycyna Wet 53:460–463

    Google Scholar 

  10. Balizs G (1999) J Chromatogr B 727:167–177 PII: S0378–4347(99)00052–3

    Article  CAS  Google Scholar 

  11. Blanchflower WJ, Cannavan A, Kennedy DG (1994) Analyst 119:1325–1328. doi:10.1039/AN9941901325

    Article  CAS  Google Scholar 

  12. Capece BP, Perez B, Castells E, Arboix M, Cristofol C (1999) J AOAC Int 82:1007–1016

    CAS  Google Scholar 

  13. Ngomuo AJ, Marriner SE, Bogan JA (1984) Vet Res Commun 8:187–193

    Article  CAS  Google Scholar 

  14. Lanusse CE, Gascon LH, Prichard RK (1995) J Vet Pharmacol Ther 18:196–203

    CAS  Google Scholar 

  15. Rose MD, Shearer G, Farrington WHH (1997) Food Addit Contam 14:15–26

    CAS  Google Scholar 

  16. Rose MD (1999) Analyst 124:1023–1026. doi:10.1039/a809058k

    Article  CAS  Google Scholar 

  17. Oxfendazole. In: Food and drugs, Chap. I––Food and Drug Administration, Department of Health and Human Services. Part 556––Tolerances for residues of new animal drugs in food. 556.495, pp 341

  18. Residues of some veterinary drugs in animals and foods. Monographs prepared by the 62nd meeting of the Joint FAO/WHO Expert Committee on Food Additives. FAO Food Nutr Pap41/16

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, National Veterinary Research Institute, Partyzantow 57, 24-100, Pulawy, Poland

    Małgorzata Olejnik, Teresa Szprengier-Juszkiewicz, Piotr Jedziniak & Jan Żmudzki

Authors
  1. Małgorzata Olejnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Teresa Szprengier-Juszkiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Piotr Jedziniak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jan Żmudzki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Małgorzata Olejnik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olejnik, M., Szprengier-Juszkiewicz, T., Jedziniak, P. et al. Do proficiency tests always verify laboratories’ performance? The case of FAPAS PT 0270. Accred Qual Assur 12, 637–641 (2007). https://doi.org/10.1007/s00769-007-0318-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00769-007-0318-x

Keywords

Search

Navigation