Abstract
The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 μg/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 μg/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 μg/ml respectively.
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Ngomuo, A.J., Marriner, S.E. & Bogan, J.A. The pharmacokinetics of fenbendazole and oxfendazole in cattle. Vet Res Commun 8, 187–193 (1984). https://doi.org/10.1007/BF02214711
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DOI: https://doi.org/10.1007/BF02214711