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Oxygenation Status in Normal Tissues, Pathological Tissues and Malignant Tumors: A pO2 Database Based on Electron Paramagnetic Resonance (EPR) Oximetry Measurements

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Abstract

The purpose of this manuscript is to provide an overview of methods that are termed EPR oximetry and to describe how these techniques have been successfully applied to characterize oxygenation status in normal and pathological tissues as well as in malignant tumors. Values in oxygenation status are presented for the following tissues: brain, kidney, liver, heart, skeletal muscle, skin, and grafts. We report basal \(p{\text{O}}_{2}\) values recorded in physiological conditions, values that may considerably vary depending on the anesthesia used. We also present the evolution of the oxygenation under pathological or ischemic states, under oxygen-enriched breathing challenge, and after pharmacological intervention. Because tumor hypoxia is a key detrimental factor in tumor progression and resistance to radiation therapy, EPR oximetry has been increasingly being used not only to characterize hypoxic tumor phenotypes but also to monitor changes in oxygen status after therapeutic interventions (i.e. oxygen or carbogen breathing, modulators of perfusion, inhibitors of oxygen consumption rate, irradiation). EPR oximetry has also been used to qualify or disqualify other oxygen imaging (PET, MRI) biomarkers. Overall, this paper presents a large comprehensive database on \(p{\text{O}}_{2}\) values recorded in different tissues and in different physiological conditions using EPR oximetry.

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Acknowledgements

I would like to express my gratitude to my dream team (docs and post-docs) who have produced, during these last 25 years, an incredible amount of excellent data in many challenging experimental models. I would like also to express my gratitude to Hal Swartz, my post-doc mentor in 1993-1994. Since then, I have appreciated his continuous support from him and Ann Flood, his wife, for my scientific activities. This article in this special issue for his 85th birthday is dedicated to him.

Funding

This research has been supported by the Foundation against Cancer (2016–087) and the Fonds National de la Recherche Scientifique FNRS (7652717F and J008220F).

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  1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCLouvain), Avenue Mounier 73.08, 1200, Brussels, Belgium

    Bernard Gallez

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Special issue: 85th birthday of Harold M. Swartz.

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Gallez, B. Oxygenation Status in Normal Tissues, Pathological Tissues and Malignant Tumors: A pO2 Database Based on Electron Paramagnetic Resonance (EPR) Oximetry Measurements. Appl Magn Reson 52, 1395–1450 (2021). https://doi.org/10.1007/s00723-021-01358-7

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