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Hemodynamic Effects of Pathological Tortuosity of the Internal Carotid Arteries Based on MRI and Ultrasound Studies

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Abstract

Our study was designed to determine the effect of different forms of pathological tortuosity of the internal carotid arteries on the formation of hemodynamic flow profile. Using a 1.5 T magnetic resonance imaging (MRI) device, 50 healthy volunteers and 43 patients with pathological tortuosity of the internal carotid arteries were studied by applying routine MRI protocol and quantitative phase-contrast MR angiography. Changes in the peak, linear and volumetric blood flow rates as well as the cross-sectional areas of the vessel were measured during the cardiac cycle within the cervical and intracranial segments of the internal carotid arteries. 20 patients with pathological tortuosity of the internal carotid arteries were subjected to ultrasound study. In both, the control group and the group with pathological tortuosity, the shape of the curves that reflects the change in the linear blood flow rate as a function of the cardiac cycle, obtained with ultrasound and MRI, qualitatively coincides and does not depend on the tested segment of the artery and its path. The correlation coefficient was low between the peak blood flow rate obtained by ultrasound and MRI. The quantitative values of the blood flow rate, obtained in the control group and the group with pathological tortuosity, differed significantly in different segments of the internal carotid arteries. However, no significant differences were observed in blood flow rates between various forms of ICA tortuosity. The cross-sectional area was significantly higher in the case of pathological tortuosity of the internal carotid arteries as compared to the control group.

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Acknowledgments

This work was financially supported by the Russian Science Foundation (project no. 14-35-00020).

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Authors and Affiliations

  1. The Institute International Tomography Center of the Russian Academy of Sciences, Institutskaya, 3a, Novosibirsk, 630090, Russian Federation

    Yu. Stankevich, O. Bogomyakova, L. Shraybman & A. Tulupov

  2. State Research Institute of Physiology and Fundamental Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Timakova, 4, Novosibirsk, 630117, Russian Federation

    M. Rezakova

  3. Novosibirsk State University, Pirogova, 2, Novosibirsk, 630090, Russian Federation

    A. Tulupov

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  1. Yu. Stankevich
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  2. M. Rezakova
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  3. O. Bogomyakova
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  4. L. Shraybman
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  5. A. Tulupov
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Correspondence to Yu. Stankevich.

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Stankevich, Y., Rezakova, M., Bogomyakova, O. et al. Hemodynamic Effects of Pathological Tortuosity of the Internal Carotid Arteries Based on MRI and Ultrasound Studies. Appl Magn Reson 46, 1109–1120 (2015). https://doi.org/10.1007/s00723-015-0708-x

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  • DOI: https://doi.org/10.1007/s00723-015-0708-x

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