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Simultaneous electroanalysis of adenine and adenosine on a poly-nicotinic acid modified pencil graphite electrode

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Abstract

This work portrays the simultaneous electrochemical analysis of adenine and adenosine on a poly-nicotinic acid modified pencil graphite electrode (poly-NA/PGE). The electrochemical behavior of the PGE and poly-NA/PGE were analyzed using cyclic voltammetry and electrochemical impedance spectroscopy. Morphological comparison of the PGE and modified PGE were done with field emission scanning electron microscopy and atomic force microscopy. Faradaic response of adenine and adenosine were observed on poly-NA/PGE at 0.95 V and 1.23 V, respectively, at neutral pH. Using differential pulse voltammetric technique, the sensor demonstrated a linear response to both adenine and adenosine from 2.0—70 µM concentration range with lower detection limits of 0.9276 μM and 0.8794 μM, respectively. The feasibility of the developed electrochemical device was also studied in blood serum and urine samples and was found to be a remarkable tool for the simultaneous electroanalysis of adenine and adenosine.

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Acknowledgements

The authors gratefully acknowledge Amrita Vishwa Vidyapeetham for providing the facilities and support to carry out the research work. Also, the authors are thankful to Amrita Center for Nano Sciences, Kochi for FE- SEM analysis, CLIF University of Kerala for AFM analysis, Department of Chemistry Kariavattom Campus, Kerala University for EIS analysis, and Amrita Center for Advanced Research in Ayurveda, for their characterization support.

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  1. Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, 690525, India

    Santhy Antherjanam & Beena Saraswathyamma

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  1. Santhy Antherjanam
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  2. Beena Saraswathyamma
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Correspondence to Beena Saraswathyamma.

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Antherjanam, S., Saraswathyamma, B. Simultaneous electroanalysis of adenine and adenosine on a poly-nicotinic acid modified pencil graphite electrode. Monatsh Chem 153, 1143–1153 (2022). https://doi.org/10.1007/s00706-022-02985-x

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