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A straightforward synthesis of potentially biologically active novel urea derivatives from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids

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Abstract

Potentially biologically active urea derivatives have been prepared in an efficient one-pot procedure from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids and characterized via several spectroscopy techniques. Ideal reaction times and temperatures, as well as the absence of metal catalysts and time-consuming and expensive purification chromatographic conditions, allowed the products to be in good yield. The obtained unsymmetrical urea derivatives in an economical and efficient synthetic methodology would be of great interest to be used for potential applications related to drug design, pharmaceutical, and medicinal chemistry.

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Acknowledgements

I would like to thank Atatürk University for taking NMR spectra and also to thank Erzurum Technical University High Technology Research Center for research conditions. I would also like to thank Prof. Dr. Süleyman Göksu for his helpful discussion.

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  1. Department of Basic Sciences, Faculty of Science, Erzurum Technical University, 25100, Erzurum, Türkiye

    Yusuf Akbaba

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  1. Yusuf Akbaba
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Correspondence to Yusuf Akbaba.

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Akbaba, Y. A straightforward synthesis of potentially biologically active novel urea derivatives from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids. Monatsh Chem 153, 1251–1259 (2022). https://doi.org/10.1007/s00706-022-02982-0

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