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Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: I. Synthesis of 1-(Adamantan-1-yl)-3-(fluoro, chlorophenyl)ureas

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Abstract

A series of 1,3-disubstituted ureas with a phenyl fragment containing fluorine and/or chlorine substituents in different positions were synthesized with yields of 33–80%. 1-Isocyanatoadamantane was prepared for the first time by the reaction of diphenylphosphoryl azide with (adamantan-1-yl)carboxylic acid in a yield of 85%.

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Funding

The work was financially supported by the Russian Science Foundation (project no. 19-73-10002).

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Authors and Affiliations

  1. Volzhsky Polytechnic Institute Branch, Volgograd State Technical University, 404121, Volzhsky, Russia

    V. V. Burmistrov & G. M. Butov

  2. Volgograd State Technical University, 400005, Volgograd, Russia

    V. V. Burmistrov, D. V. Danilov, V. S. D’yachenko, E. V. Rasskazova & G. M. Butov

Authors
  1. V. V. Burmistrov
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  2. D. V. Danilov
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  3. V. S. D’yachenko
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  4. E. V. Rasskazova
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  5. G. M. Butov
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Correspondence to G. M. Butov.

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Burmistrov, V.V., Danilov, D.V., D’yachenko, V.S. et al. Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: I. Synthesis of 1-(Adamantan-1-yl)-3-(fluoro, chlorophenyl)ureas. Russ J Org Chem 56, 735–740 (2020). https://doi.org/10.1134/S1070428020050024

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