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Synthesis of novel 1,2- and 2-substituted benzimidazoles with high antibacterial and antioxidant activity

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Abstract

Benzimidazole derivatives are potential candidates for drug development. They are efficiently synthesized and possess various biological properties including antibacterial activity. A series of functionalized benzimidazole derivatives bearing N-(4-chloro- or fluorophenyl)pyrrolidin-2-one or N-(4-chloro- or fluorophenyl)aminobutanoic acid moiety were synthesized. Compounds possessing a very high antibacterial activity, comparable to that of a commercial antibacterial agent oxytetracycline, against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus were identified. Some of the synthesized compounds exhibited significant antioxidant activity.

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Authors and Affiliations

  1. Department of Organic Chemistry, Kaunas University of Technology, 50254, Kaunas, Lithuania

    Ingrida Tumosienė, Artūras Peleckis, Ilona Jonuškienė, Rita Vaickelionienė, Zigmuntas Jonas Beresnevičius & Vytautas Mickevičius

  2. Department of Physical and Inorganic Chemistry, Kaunas University of Technology, 50254, Kaunas, Lithuania

    Kristina Kantminienė

  3. Department of Veterinary Pathobiology, Veterinary Academy, Lithuanian University of Health Sciences, 47181, Kaunas, Lithuania

    Jūratė Šiugždaitė

Authors
  1. Ingrida Tumosienė
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  2. Artūras Peleckis
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  3. Ilona Jonuškienė
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  4. Rita Vaickelionienė
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  5. Kristina Kantminienė
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  6. Jūratė Šiugždaitė
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  7. Zigmuntas Jonas Beresnevičius
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  8. Vytautas Mickevičius
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Corresponding author

Correspondence to Kristina Kantminienė.

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Tumosienė, I., Peleckis, A., Jonuškienė, I. et al. Synthesis of novel 1,2- and 2-substituted benzimidazoles with high antibacterial and antioxidant activity. Monatsh Chem 149, 577–594 (2018). https://doi.org/10.1007/s00706-017-2066-x

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  • DOI: https://doi.org/10.1007/s00706-017-2066-x

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