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Stereoselective total synthesis of verbalactone

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Abstract

A simple and efficient route for the stereoselective total synthesis of verbalactone from commercially available inexpensive starting material d-mannitol using Barbier allylation, α-aminoxylation, and Yamaguchi macrolactonization as key steps is reported.

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Acknowledgments

We are grateful to CSIR-IICT, Hyderabad for providing analytical facilities

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, 522510, Andhra Pradesh, India

    Gurrala Alluraiah, Reddymasu Sreenivasulu, Indraganti Sreenivasa Murthy & Rudraraju Ramesh Raju

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  1. Gurrala Alluraiah
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  2. Reddymasu Sreenivasulu
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  3. Indraganti Sreenivasa Murthy
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  4. Rudraraju Ramesh Raju
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Corresponding author

Correspondence to Rudraraju Ramesh Raju.

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Alluraiah, G., Sreenivasulu, R., Sreenivasa Murthy, I. et al. Stereoselective total synthesis of verbalactone. Monatsh Chem 145, 2019–2024 (2014). https://doi.org/10.1007/s00706-014-1272-z

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  • DOI: https://doi.org/10.1007/s00706-014-1272-z

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