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A concise stereoselective total synthesis of verbalactone

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Abstract

A stereoselective total synthesis of macrodilactone, verbalactone is reported. The strategy utilizes an iterative Jacobsen hydrolytic kinetic resolution, nucleophilic ring opening, and macrolactonisation under Yamaguchi reaction conditions as the key steps.

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Acknowledgments

We are grateful to JNTU for constant encouragement during this research program and GVK BIO, Hyderabad for providing analytical facilities.

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Authors and Affiliations

  1. GVK Biosciences Private Limited, Nacharam, IDA Mallapur, Hyderabad, Telangana, 500076, India

    Mahesh Madala, Balamurali Raman & Sridhar Musulla

  2. Department of Chemistry, JNT University, Hyderabad, Telangana, 500082, India

    Mahesh Madala & Sridhar Musulla

  3. Teegala Krishna reddy college of Pharmacy, Medbowli, Meerpet, Saroornagar, Hyderabad, Telangana, 500097, India

    K. V. Sastry

Authors
  1. Mahesh Madala
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  2. Balamurali Raman
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  3. K. V. Sastry
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  4. Sridhar Musulla
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Corresponding author

Correspondence to Mahesh Madala.

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Madala, M., Raman, B., Sastry, K.V. et al. A concise stereoselective total synthesis of verbalactone. Monatsh Chem 147, 1985–1990 (2016). https://doi.org/10.1007/s00706-016-1682-1

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  • DOI: https://doi.org/10.1007/s00706-016-1682-1

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