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Microwave-assisted synthesis of fused tricyclic pyrazino[1,2-a]indole derivatives

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Abstract

A microwave-assisted expedient route for the synthesis of novel 3-phenylpyrazino[1,2-a]indol-1(2H)-one derivatives is reported. The method has advantages such as accelerated reaction rate, excellent yields, simplicity of operation, and is eco-friendly. Microwave heating of ammonium acetate generates the NH3 nucleophile required for the cyclization reaction and acetic acid.

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Acknowledgments

The authors thank Council for Scientific and Industrial Research (CSIR) New Delhi for financial assistance for this work and the Principal, K. T. H. M. College, Nashik - 422 002 for facilities.

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Authors and Affiliations

  1. Department of Chemistry, K. R. T. Arts, B. H. Commerce and A. M. Science College, University of Pune (MS), Gangapur Road, Nashik, 422 002, India

    Raghunath Toche, Sunil Chavan & Ravindra Janrao

Authors
  1. Raghunath Toche
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  2. Sunil Chavan
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  3. Ravindra Janrao
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Correspondence to Raghunath Toche.

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Toche, R., Chavan, S. & Janrao, R. Microwave-assisted synthesis of fused tricyclic pyrazino[1,2-a]indole derivatives. Monatsh Chem 145, 1507–1512 (2014). https://doi.org/10.1007/s00706-014-1216-7

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  • DOI: https://doi.org/10.1007/s00706-014-1216-7

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