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Microwave-assisted green approach toward the unexpected synthesis of pyrazole-4-carboxylates

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Abstract

A practically efficient, environment friendly, and solvent free microwave-assisted protocol was developed for the synthesis of pyrazole-4-carboxylates. In this connection, we synthesized five new compounds (4a-4e) via microwave irradiation of a mixture of benzophenone hydrazones and acetoacetates in the absence of solvent. Short reaction time, easy workup and quantitative yield are the striking features of our protocol.

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Acknowledgments

The authors are thankful for their financial support to Higher Education Commission (HEC), Pakistan to Project No. 20-1910 under National Research Program for Universities.

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Authors and Affiliations

  1. H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

    Arshia, Syed Muhammad Saad & Khalid Mohammed Khan

  2. PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, 75280, Pakistan

    Shahnaz Perveen

  3. Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler-Str. 4, 72076, Tübingen, Germany

    Wolfgang Voelter

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  1. Arshia
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  2. Syed Muhammad Saad
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  4. Khalid Mohammed Khan
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  5. Wolfgang Voelter
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Correspondence to Khalid Mohammed Khan.

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Arshia, Saad, S.M., Perveen, S. et al. Microwave-assisted green approach toward the unexpected synthesis of pyrazole-4-carboxylates. J IRAN CHEM SOC 13, 1405–1410 (2016). https://doi.org/10.1007/s13738-016-0855-5

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  • DOI: https://doi.org/10.1007/s13738-016-0855-5

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