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Physicochemical studies on the interaction of gold(III) trichlorophenanthridine complex with calf thymus DNA

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Abstract

The interaction of gold(III) trichlorophenanthridine complex, [Au(phend)Cl3], with calf thymus DNA was investigated by UV–Vis absorption, circular dichroism, and fluorescence spectrophotometery as well as viscometry, cyclic voltammetry (CV), and molecular docking. The values of binding constants K b (obtained by UV–Vis) and K f (obtained by fluorescence) are 3 × 104 and 7.68 × 105 M−1, respectively. Evidence for intercalation comprised a hyperchromic effect at 210 nm and a hypochromic effect at 250 nm caused by the ligand, increasing the T m of DNA, increasing of viscosity, increasing the intensity of the positive peak, decreasing the intensity of the negative peak, and the positive shift of the cathodic peak potential in CV.

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Acknowledgments

Financial support of Damghan University is acknowledged.

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Authors and Affiliations

  1. School of Chemistry, Damghan University, Damghan, Iran

    Sasan Moradi, Davood Ajloo & Robabeh Alizadeh

  2. School of Biology, Damghan University, Damghan, Iran

    Taghi Lashkarbolouki

  3. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    Ali Akbar Saboury

Authors
  1. Sasan Moradi
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  2. Davood Ajloo
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  3. Taghi Lashkarbolouki
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  4. Robabeh Alizadeh
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  5. Ali Akbar Saboury
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Correspondence to Davood Ajloo.

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Moradi, S., Ajloo, D., Lashkarbolouki, T. et al. Physicochemical studies on the interaction of gold(III) trichlorophenanthridine complex with calf thymus DNA. Monatsh Chem 144, 1499–1505 (2013). https://doi.org/10.1007/s00706-013-1032-5

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  • DOI: https://doi.org/10.1007/s00706-013-1032-5

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