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Contributions to syntheses of pyrrolo[2,1-a]phthalazines

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Abstract

Structural elucidation of the dihydro derivatives obtained as by-products in the classic salt method synthesis of pyrrolo[2,1-a]phthalazines and acetylenic dipolarophiles was achieved by X-ray diffraction analysis of a representative compound. In addition, new pyrrolo[2,1-a]phthalazines were obtained by a one-pot three-component reaction that avoids the formation of the dihydro derivative intermediates.

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Acknowledgments

M.R.C. thanks the University of Cape Town and the National Research Foundation for research support.

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Authors and Affiliations

  1. Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa

    Mino R. Caira

  2. Oltchim Research Center, St. Uzinei 1, 240050, Ramnicu Valcea, Romania

    Emilian Georgescu & Florentina Georgescu

  3. Centre of Organic Chemistry “C. D. Nenitzescu”, Roumanian Academy, Spl Independenţei 202B, 060023, Bucharest, Romania

    Florin Albota & Florea Dumitrascu

Authors
  1. Mino R. Caira
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  2. Emilian Georgescu
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  3. Florentina Georgescu
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  4. Florin Albota
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  5. Florea Dumitrascu
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Corresponding author

Correspondence to Florea Dumitrascu.

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Caira, M.R., Georgescu, E., Georgescu, F. et al. Contributions to syntheses of pyrrolo[2,1-a]phthalazines. Monatsh Chem 142, 743–748 (2011). https://doi.org/10.1007/s00706-011-0468-8

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  • DOI: https://doi.org/10.1007/s00706-011-0468-8

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