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Synthesis of new Benzo[f]isoindole-4,9-diones as anticancer compounds

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An Erratum to this article was published on 11 March 2010

Abstract

The design and synthesis of monosubstituted and disubstituted azanaphthoquinone annelated pyrroles with anticancer activity are described. N-alkylation with various side chains at the pyrrole ring led to a series of monosubstituted products. For preparation of disubstituted isoindole derivatives, appropriately substituted tosyl methyl isocyanides were used. The biological activity of all the compounds was evaluated against a number of cancer cell lines.

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Acknowledgments

N. Pongprom thanks “The Royal Thai Government Scholarship” for financial support throughout her Ph.D. program.

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Authors and Affiliations

  1. Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria

    Nipawan Pongprom, Hans Bachitsch, Arnulf Bauchinger, Hamid Ettefagh, Tanja Haider, Manuela Hofer, Heike Knafl, Rita Slanz, Markus Waismeyer, Friedrich Wieser & Helmut Spreitzer

Authors
  1. Nipawan Pongprom
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  2. Hans Bachitsch
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  3. Arnulf Bauchinger
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  4. Hamid Ettefagh
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  5. Tanja Haider
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  6. Manuela Hofer
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  7. Heike Knafl
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  8. Rita Slanz
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  9. Markus Waismeyer
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  10. Friedrich Wieser
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  11. Helmut Spreitzer
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Corresponding authors

Correspondence to Nipawan Pongprom or Helmut Spreitzer.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00706-010-0286-4

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Pongprom, N., Bachitsch, H., Bauchinger, A. et al. Synthesis of new Benzo[f]isoindole-4,9-diones as anticancer compounds. Monatsh Chem 141, 53–62 (2010). https://doi.org/10.1007/s00706-009-0219-2

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  • DOI: https://doi.org/10.1007/s00706-009-0219-2

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