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Genetics of impulse control disorders in Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Impulse control disorders (ICD) have been recognised in Parkinson’s disease (PD) as adverse effects of dopamine replacement therapy, particularly with dopamine agonists. Although virtually all PD patients are treated with dopaminergic drugs, only a minority will develop hyperdopaminergic states, suggesting predisposing and/or protecting factors. The age at onset, the sex and the dose or type of dopaminergic drugs have been identified as clinical predictive factors. Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway (COMT, DAT), dopamine receptors (DRD1, DRD2, DRD3, DRD4), serotonin receptors and its transporter (HTR2A, 5HTT), and glutamate receptors (GRIN2B). Although validation in larger and independent cohorts is needed, the results from these studies give us some insights into the pathophysiology of hyperdopaminergic states and may be useful, at term, in personalising antiparkinsonian treatment in clinical practice.

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Authors and Affiliations

  1. Assistance Publique Hôpitaux de Paris, Department of Neurology, INSERM, CIC-9503, Pitié-Salpêtrière Hospital, Paris, France

    Florence Cormier, Julia Muellner & Jean-Christophe Corvol

  2. INSERM, UMRS975, UPMC, CR-ICM, CNRS UMR7225, Pitié-Salpêtrière Hospital, Paris, France

    Jean-Christophe Corvol

  3. CIC Neuro, Bâtiment ICM, Hôpital Pitié-Salpêtrière, 47-83 Bd de l’Hôpital, 75013, Paris, France

    Jean-Christophe Corvol

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  1. Florence Cormier
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Correspondence to Jean-Christophe Corvol.

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Cormier, F., Muellner, J. & Corvol, JC. Genetics of impulse control disorders in Parkinson’s disease. J Neural Transm 120, 665–671 (2013). https://doi.org/10.1007/s00702-012-0934-4

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