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Dopamine Genes and Pathological Gambling in Discordant Sib-Pairs

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Abstract

Pathological gambling (PG) is an impulse control disorder that has been considered as a behavioral addiction. Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported. In the present study, 140 sib-pairs discordant for the diagnosis of PG (70 males and 70 females on each group) were recruited through the Gambling Outpatient Unit at the Institute of Psychiatry, University of Sao Paulo and were assessed by trained psychiatrists. A family-based association design was chosen to prevent population stratification. All subjects were genotyped for dopamine receptor genes (DRD1 −800 T/C, DRD2 TaqIA RFLP, DRD3 Ser9Gly, DRD4 48bp exon III VNTR, DRD5 (CA) repeat) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Our results suggest the association of PG with DRD1 −800 T/C allele T (P = .03).

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Acknowledgements

This study was supported by funds from The State of São Paulo Research Funding Agency (02/02653-87 and 02/0009-3) and the Ontario Problem Gambling Research Centre. We thank the Gambling Outpatient Unit group in São Paulo for help with data collection. We also thank the Laboratory of Medical Investigation LIM-23 (Institute of Psychiatry, University of São Paulo) and the Neurogenetics Laboratory staff (Centre for Addiction and Mental Health, University of Toronto) for genotyping assistance.

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Authors and Affiliations

  1. Laboratory of Medical Investigation (LIM-23)—Psychopharmacology, Department and Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil

    Daniela Sabbatini da Silva Lobo, Homero P. Vallada & Valentim Gentil

  2. Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Neurogenetics Section—R 32, Toronto, ON, Canada, M5T1R8

    Daniela Sabbatini da Silva Lobo & James L. Kennedy

  3. Social and Genetics Developmental Psychiatry, Institute of Psychiatry, Kings College of London, London, UK

    Joanne Knight

  4. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Silvia S. Martins

  5. Gambling Outpatient Unit, Department and Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil

    Hermano Tavares

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  1. Daniela Sabbatini da Silva Lobo
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Correspondence to Daniela Sabbatini da Silva Lobo.

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This study was performed at the Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil

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Sabbatini da Silva Lobo, D., Vallada, H.P., Knight, J. et al. Dopamine Genes and Pathological Gambling in Discordant Sib-Pairs. J Gambl Stud 23, 421–433 (2007). https://doi.org/10.1007/s10899-007-9060-x

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