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Na+,K+-ATPase activity in an animal model of mania

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

We evaluated Na+,K+-ATPase activity in hippocampus of rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine or saline was administered to rats for 14 days, between day 8 and 14, rats were treated with lithium, valproate or saline. In the maintenance treatment, rats were treated with lithium, valproate or saline, between day 8 and 14, amphetamine or saline were administered. Locomotor activity was assessed by open field test and Na+,K+-ATPase activity was measured. Our results showed that mood stabilizers reversed and prevented amphetamine-induced behavioral effects. Moreover, amphetamine (acute treatment) increased Na+,K+-ATPase activity, and administration of lithium or valproate reversed this effect. In the maintenance treatment, amphetamine increased Na+,K+-ATPase activity in saline-pretreated rats. Amphetamine administration in lithium- or valproate-pretreated animals did not alter Na+,K+-ATPase activity. The findings suggest that amphetamine-induced hyperactivity may be associated with an increase in Na+,K+-ATPase.

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Acknowledgments

This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio à Pesquisa Científica e Tecnológica do Estado de Santa Catarina (FAPESC) and Universidade do Extremo Sul Catarinense (UNESC).

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Authors and Affiliations

  1. Laboratório de Neurociências, Unidade Acadêmica de Ciências da Saúde, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    Alexandra I. Zugno, Samira S. Valvassori, Camila L. Ferreira & João Quevedo

  2. Laboratório de Erros Inatos do Metabolismo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Emilene B. S. Scherer, Cristiane Mattos, Cristiane Matté & Angela T. S. Wyse

  3. Laboratório de Fisiopatologia Experimental, Unidade Acadêmica de Ciências da Saúde, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    Gislaine T. Rezin & Emilio L. Streck

Authors
  1. Alexandra I. Zugno
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  2. Samira S. Valvassori
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  3. Emilene B. S. Scherer
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  4. Cristiane Mattos
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  5. Cristiane Matté
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  6. Camila L. Ferreira
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  7. Gislaine T. Rezin
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  8. Angela T. S. Wyse
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  9. João Quevedo
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  10. Emilio L. Streck
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Corresponding author

Correspondence to Emilio L. Streck.

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Zugno, A.I., Valvassori, S.S., Scherer, E.B.S. et al. Na+,K+-ATPase activity in an animal model of mania. J Neural Transm 116, 431–436 (2009). https://doi.org/10.1007/s00702-009-0198-9

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  • DOI: https://doi.org/10.1007/s00702-009-0198-9

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