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Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors

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Abstract

Chiral materials have drawn the widespread attention for their its chiral recognition ability. The design and synthesis of chiral material are of importance owing to the unpredictability in controlling chirality during the synthesis process. To circumvent problems, a chiral MOF (D-His-ZIF-8) was synthesized by ligand exchange of 2-methylimidazole (Hmim) on ZIF-8 by D-histidine (D-His), which can be treated as chiral host to distinguish amino acid enantiomers. The obtained D-His-ZIF-8 can provide chiral nanochannels for amino acid guests. Meanwhile, polynary transition-metal ion (Co2+ and Fe3+) coordinating with polydopamine (PDA) wrapped on the surface of D-His-ZIF-8 can increase the active sites. The electrochemical chiral recognition behavior showed that D-His-ZIF-8@CoFe-PDA exhibited good recognition of the tryptophan enantiomer (L/D-Trp) (working potential of −0.2 V vs. Hg/HgCl2). The LOD and LOQ of L-Trp were 0.066 mM and 0.22 mM, respectively, while the LOD and LOQ of D-Trp were 0.15 mM and 0.50 mM, respectively. Finally, the usefulness of D-His-ZIF-8@CoFe-PDA/GCE was evaluated with a recovery of 94.4–103%. The analysis of real  samples shows that D-His-ZIF-8@CoFe-PDA/GCE is a feasible sensing platform for the detection of L-Trp and D-Trp.

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Funding

This work was supported by the National Nature Science Foundations of China (grant no. 22065021), the Key Research Program of Gansu Province (21YF5GA076), the Province Nature Science Foundations of Gansu (grant no. 21JR7RA213), the Lanzhou Talent Innovation and Entrepreneurship Project (grant no. 2022-RC-33), the Hongliu Outstanding Youth Teacher Cultivate Project of Lanzhou University of Technology, and the Hongliu Excellent Youth Teacher Cultivate Project of Lanzhou University of Technology.

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  1. College of Petrochemical Technology, Lanzhou University of Technology, 730050, Lanzhou, People’s Republic of China

    Xiaohui Niu, Rui Zhao, Simeng Yan, Hongxia Li, Kunjie Cao, Xiaoyu Liu & Kunjie Wang

  2. Gansu Guoxin Runda Analysis and Testing Center, 730010, Lanzhou, People’s Republic of China

    Jing Yang

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  1. Xiaohui Niu
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Niu, X., Zhao, R., Yan, S. et al. Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors. Microchim Acta 190, 230 (2023). https://doi.org/10.1007/s00604-023-05807-x

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