Abstract
A 75-year-old woman was hospitalized due to a right axillary mass. She had undergone a resection of thyroid carcinoma 13 years earlier, followed by two subsequent operations for recurrent thyroid disease. A physical examination revealed a right axillary mass associated with skin ulceration. Persistent bleeding was observed at the skin ulcer associated with the right axillary lymph node, despite conservative treatment for the lesion. Surgery was thus performed to control persistent bleeding from the axillary ulcer, and a histopathological examination resulted in a diagnosis of poorly differentiated thyroid carcinoma. The postoperative course was uneventful, but marked leukocytosis and extensive skin metastases were recognized 30 days postoperatively. A systemic examination revealed no other lesions associated with marked leukocytosis, but elevated levels of granulocyte colony-stimulating factor were noted in a blood examination. As a result, her general condition deteriorated rapidly and the patient died 2 weeks after the onset of leukocytosis.
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References
K Sato Y Fujii T Kakiuchi K Kasono H Imamura Y Kondo et al. (1989) ArticleTitleParaneoplastic syndrome of hypercalcemia and leukocyto-sis caused by squamous cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1α, and granulocyte colony-stimulating factor Cancer Res 49 4740–6 Occurrence Handle2474371 Occurrence Handle1:CAS:528:DyaL1MXlsFWgsrg%3D
T Enomoto H Sugawa D Inoue M Miyamoto S Kosugi T Takahashi et al. (1990) ArticleTitleEstablishment of a human undifferentiated thyroid cancer cell line producing several growth factors and cytokines Cancer 65 1971–9 Occurrence Handle2196988 Occurrence Handle1:STN:280:DyaK3czit1eisg%3D%3D
K Nakamura T Takahashi R Tsuyuoka Y Ueda A Suzuki Y Okuno et al. (1991) ArticleTitleIdentification of colony-stimulating factor activity in patients with malignant tumors associated with excessive leukocytosis Jpn J Clin Oncol 21 395–9 Occurrence Handle1666658 Occurrence Handle1:STN:280:By2B3M7otlQ%3D
N Shijubo Y Inoue M Hirasawa T Igarashi M Mori A Matsuura et al. (1992) ArticleTitleGranulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung Intern Med 31 277–80 Occurrence Handle1376180 Occurrence Handle1:STN:280:By2B1cfksFY%3D
N Omura S Abe K Hirai T Aoki (1999) ArticleTitleA case of granulocyte-colony stimulating factor producing gallbladder cancer Am J Gastroenterol 94 273–5 Occurrence Handle9934773 Occurrence Handle10.1111/j.1572-0241.1999.00817.x Occurrence Handle1:STN:280:DyaK1M7jtFCksA%3D%3D
D Komatsu M Sakurai H Nakafuji N Koide H Morishita T Nakamura (2003) ArticleTitleGranulocyte colony stimulating factor-producing collision tumor of the gastric cardia J Gastroenterol 38 1013–25 Occurrence Handle14614613 Occurrence Handle10.1007/s00535-003-1188-6
T Kitanishi M Suzuki J Fukui K Taniguchi H Kitano Y Yazawa et al. (2000) ArticleTitleTwo cases of thyroid carcinoma producing granulocyte colony-stimulating factor J Otolaryngol 29 174–8 Occurrence Handle10883833 Occurrence Handle1:STN:280:DC%2BD3M%2FjtFCgsw%3D%3D
N Fukushima E Sasatomi O Tokunaga M Miyahara (2001) ArticleTitleA case of pancreatic cancer with production of granulocyte colony-stimulating factor Am J Gastroenterol 96 258–9 Occurrence Handle11197273 Occurrence Handle10.1111/j.1572-0241.2001.03495.x Occurrence Handle1:STN:280:DC%2BD3M7gslGnsQ%3D%3D
S Asano A Urabe T Okabe N Sato Y Kondo (1977) ArticleTitleDemonstration of granulopoietic factors in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue Blood 49 845–52 Occurrence Handle300638 Occurrence Handle1:STN:280:CSiC2MfotFE%3D
T Nakada H Sato F Inoue F Mizorogi K Nagayama T Tanaka (1996) ArticleTitleThe production of colony-stimulating factors by thyroid carcinoma is associated with marked neutrophilia and eosinophilia Intern Med 35 815–20 Occurrence Handle8933194 Occurrence Handle1:STN:280:ByiD1cjhslI%3D
L Balducci SW Chapman DD Little CL Hardy (1989) ArticleTitleParaneoplastic eosinophilia: report of a case with in vitro studies of hemopoiesis Cancer 64 2250–3 Occurrence Handle2804915 Occurrence Handle1:STN:280:By%2BD3s%2Fht1E%3D
K Saito Y Tomotsune K Yamamoto T Saito T Kuzuya S Yoshida (1980) ArticleTitleA case of primary squamous cell carcinoma of the thyroid associated with marked neutrophilia and hypercalcemia (in Japanese) Nippon Naika Gakkai Zasshi 68 88–94
S Takashima S Morimoto J Ikezoe Y Kokado T Kozuka (1990) ArticleTitleOccult anaplastic thyroid carcinoma associated with marked hypercalcemia J Clin Ultrasound 18 438–41 Occurrence Handle2161019 Occurrence Handle1:STN:280:By%2BB28vlt1U%3D
S Yazawa H Toshimori K Nakatsuru H Katakami J Takemura S Matsukura (1995) ArticleTitleThyroid anaplastic carcinoma producing granulocyte-colony-stimulating factor and parathyroid hormone-related protein Intern Med 34 584–8 Occurrence Handle7549149 Occurrence Handle1:STN:280:BymD3M3jvFA%3D
K Iwasa M Noguchi K Mori N Ohta I Miyazaki A Nonomura et al. (1995) ArticleTitleAnaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): report of a case Surg Today 25 158–60 Occurrence Handle7539648 Occurrence Handle10.1007/BF00311090 Occurrence Handle1:STN:280:ByqB1M%2Fos1I%3D
S Hoshi S Yoshizawa H Arioka N Kobayashi K Kudo H Niino (2000) ArticleTitleAnaplastic thyroid carcinoma with lung metastasis producing CA19-9 and GM-CSF (in Japanese with English abstract) Nippon Kokyuuki Gakkai Zasshi (J Jpn Resp Soc) 38 391–7 Occurrence Handle1:STN:280:DC%2BD3cvotFynsg%3D%3D
T Sato M Omura J Saito A Hirasawa Y Kakuta Y Wakabayashi et al. (2000) ArticleTitleNeutrophilia associated with anaplastic carcinoma of the thyroid: production of macrophage colony-stimulating factor (M-CSF) and interleukin-6 Thyroid 10 1113–8 Occurrence Handle11201858 Occurrence Handle1:STN:280:DC%2BD3M7jvFyrtg%3D%3D Occurrence Handle10.1089/thy.2000.10.1113
T Saeki S Saeki H Yokoyama F Fukuda R Sato C Morooka et al. (1990) ArticleTitleA case of colony stimulating factor (CSF) producing gastric cancer (in Japanese with English abstract) Gann no Rinsho (Jpn J Cancer Clin) 36 2469–74 Occurrence Handle1:STN:280:By6D28nktlA%3D
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Fujita, T., Ogasawara, Y., Naito, M. et al. Anaplastic Thyroid Carcinoma Associated with Granulocyte Colony-Stimulating Factor: Report of a Case. Surg Today 36, 63–67 (2006). https://doi.org/10.1007/s00595-005-3100-x
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DOI: https://doi.org/10.1007/s00595-005-3100-x