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Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy

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Abstract

Liver cirrhosis patients generally progress to liver failure. To cure this progressive disease, we developed a novel cell therapy using bone marrow cells; autologous bone marrow cell infusion (ABMi) therapy. We previously described the possible action mechanism of ABMi therapy in the cirrhotic liver, and showed the timeline and results of clinical studies of ABMi therapy. We have also carried out other clinical studies using bone marrow cells and granulocyte colony-stimulating factor. Here, we report a new randomized clinical trial to evaluate the effects of ABMi therapy. However, ABMi therapy may not be possible in patients who are unable to undergo general anesthesia; therefore, we have started to develop a next-generation stem cell therapy using cultured mesenchymal stem cells.

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Acknowledgments

This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS); Ministry of Health, Labour and Welfare, Health and Labour Sciences Research Grants; and the Japan Science and Technology Agency (JST) Project for Realization of Regenerative Medicine and the Highway Program.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi, 755-8505, Japan

    Shuji Terai, Haruko Tanimoto, Masaki Maeda, Junichi Zaitsu, Takuro Hisanaga, Takuya Iwamoto, Koichi Fujisawa, Yuko Mizunaga, Toshihiko Matsumoto, Yohei Urata, Yoshio Marumoto, Isao Hidaka, Tsuyoshi Ishikawa, Yuichiro Yokoyama, Koji Aoyama, Masako Tsuchiya, Taro Takami, Kaoru Omori, Naoki Yamamoto, Makoto Segawa, Koichi Uchida, Takahiro Yamasaki & Isao Sakaida

  2. Social Insurance Allied Shimonoseki Kosei Hospital, Shimonoseki, Japan

    Kiwamu Okita

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  1. Shuji Terai
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  2. Haruko Tanimoto
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Correspondence to Shuji Terai.

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Terai, S., Tanimoto, H., Maeda, M. et al. Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy. J Gastroenterol 47, 491–497 (2012). https://doi.org/10.1007/s00535-012-0580-5

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  • DOI: https://doi.org/10.1007/s00535-012-0580-5

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