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Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments

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Abstract

Purpose

Chemotherapy-induced peripheral neuropathy (CIPN) commonly involves hand dexterity impairment. However, the factors affecting hand dexterity impairment are unknown and there is currently no established treatment. The purpose of the current study was to clarify factors influencing hand dexterity impairment in taxane-induced peripheral neuropathy using subjective and objective assessments.

Methods

We assessed patient characteristics, treatment-related factors, subjective symptoms of CIPN (Patient Neurotoxicity Questionnaire [PNQ]), psychological symptoms, and upper limb dysfunction (Quick Disabilities of the Arm, Shoulder and Hand [Quick DASH]). Quantitative assessments were pinch strength, sensory threshold, hand dexterity impairment, and grip force control. Multiple regression analysis was performed using hand dexterity impairment as the dependent variable and age and PNQ, Quick DASH, and control of grip force as independent variables.

Results

Forty-three breast cancer patients were included in the analysis. Hand dexterity impairment in taxane-induced peripheral neuropathy patients was significantly correlated with age, grip force control, and PNQ sensory scores (p < 0.008). Multiple regression analysis demonstrated that PNQ sensory scores and grip force control were significantly associated with hand dexterity impairment (p < 0.01).

Conclusion

Subjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy.

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Data availability

The datasets are available from the corresponding author on reasonable request.

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Acknowledgements

The authors are extremely grateful to the breast cancer survivors who participated in this study, and Izumi Kameyama, Yumi Nakakura, Yasuko Tanaka, and Naoko Takahashi for assistance with data collection. We thank Benjamin Knight, MSc., from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Author information

Authors and Affiliations

  1. Department of Rehabilitation, Breast Care Sensyu Clinic, Osaka, Japan

    Masahiro Manfuku

  2. Division of Rehabilitation Medicine, Kobe University Hospital International Clinical Cancer Research Center, Hyogo, Japan

    Junichiro Inoue

  3. Department of Rehabilitation Medicine, Nara Medical University, Nara, Japan

    Nobuki Yamanaka

  4. Department of Breast Surgery, Breast Care Sensyu Clinic, Osaka, Japan

    Hiroe Kanamori & Kazuhiro Sumiyoshi

  5. Graduate School of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-Cho, Kitakatsuragi-Gun, Nara, 635-0832, Japan

    Michihiro Osumi

Authors
  1. Masahiro Manfuku
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  2. Junichiro Inoue
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  3. Nobuki Yamanaka
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  4. Hiroe Kanamori
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  5. Kazuhiro Sumiyoshi
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  6. Michihiro Osumi
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Contributions

All authors contributed significantly to the preparation of this manuscript. Concept/idea/research design: Manfuku M, Inoue J, Osumi M. Writing: Manfuku M, Inoue J, Yamanaka N, Osumi M. Data collection: Manfuku M, Osumi M, Knamori H, Sumiyoshi K. Data analysis: Manfuku M, Osumi M. Project management: Manfuku M, Inoue J, Osumi M. Providing participants: Sumiyoshi K.

Corresponding author

Correspondence to Michihiro Osumi.

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Competing interests

The authors declare no competing interests.

Ethics approval, consent to participate, and consent for publication

This study received ethical approval from the Ethics Committee of the Japanese Physical Therapy Association (ER02-005). All participants provided written informed consent to participate in the study, and consented to the presentation or publishing of anonymized data. The study was conducted in accordance with the Declaration of Helsinki.

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Manfuku, M., Inoue, J., Yamanaka, N. et al. Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments. Support Care Cancer 32, 304 (2024). https://doi.org/10.1007/s00520-024-08504-4

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