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Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer

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Abstract

Purpose

This study aimed to test the feasibility and acceptability of a digital health promotion intervention for family caregivers of patients with advanced colorectal cancer and explore the intervention’s preliminary efficacy for mitigating the impact of caregiving on health and well-being.

Methods

We conducted a single-arm pilot feasibility trial of C-PRIME (Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life), an 8-week digital health-promotion behavioral intervention involving monitoring and visualizing health-promoting behaviors (e.g., objective sleep and physical activity data) and health coaching (NCT05379933). A priori benchmarks were established for feasibility (≥ 50% recruitment and objective data collection; ≥ 75% session engagement, measure completion, and retention) and patient satisfaction (> 3 on a 1–5 scale). Preliminary efficacy was explored with pre- to post-intervention changes in quality of life (QOL), sleep quality, social engagement, and self-efficacy.

Results

Participants (N = 13) were M = 52 years old (SD = 14). Rates of recruitment (72%), session attendance (87%), assessment completion (87%), objective data collection (80%), and retention (100%) all indicated feasibility. All participants rated the intervention as acceptable (M = 4.7; SD = 0.8). Most participants showed improvement or maintenance of QOL (15% and 62%), sleep quality (23% and 62%), social engagement (23% and 69%), and general self-efficacy (23% and 62%).

Conclusion

The C-PRIME digital health promotion intervention demonstrated feasibility and acceptability among family caregivers of patients with advanced colorectal cancer. A fully powered randomized controlled trial is needed to test C-PRIME efficacy, mechanisms, and implementation outcomes, barriers, and facilitators in a divserse sample of family caregivers.

Trial registration

The Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life (C-PRIME) study was registered on clinicaltrials.gov, NCT05379933, in May 2022.

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Data availability

Data are available from the corresponding author upon reasonable request. The data are not publicly available due to privacy restrictions.

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Funding

Dr. Brian Gonzalez received funding for this work from Moffitt Cancer Center.

Author information

Authors and Affiliations

  1. Department of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Lisa M. Gudenkauf, Xiaoyin Li, Aasha I. Hoogland, Laura B. Oswald, Heather S. L. Jim, Yvelise Rodriguez, Crystal A. Bryant, Kellie N. Zambrano, Kerie O. Walters & Brian D. Gonzalez

  2. Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA

    Iman lmanirad & Jennifer B. Permuth

  3. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA

    Jennifer B. Permuth

  4. School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Brent J. Small

  5. Department of Family Medicine, University of Vermont, Burlington, VT, USA

    Maija Reblin

Authors
  1. Lisa M. Gudenkauf
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  2. Xiaoyin Li
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  3. Aasha I. Hoogland
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  4. Laura B. Oswald
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  6. Jennifer B. Permuth
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  8. Heather S. L. Jim
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  9. Yvelise Rodriguez
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  13. Maija Reblin
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  14. Brian D. Gonzalez
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Contributions

L.G.: methodology, formal analysis and investigation, writing—original draft preparation, writing–review, and editing; X.L.: data collection, formal analysis and investigation, writing—original draft preparation, writing—review and editing; A.H.: writing—review and editing; LO.: writing—review and editing; I.l: writing—review and editing; B.S.: writing—review and editing; H.J.: writing—review and editing; Y.R.: data collection, writing—review, and editing; C.B.: regulatory support, writing—review, and editing; K.Z.: data collection, writing—review, and editing; K.W.: data collection, writing—review, and editing; M.R.: conceptualization, methodology, data collection, writing—original draft preparation, writing—review and editing, funding acquisition, resources, supervision; B.G.: conceptualization, methodology, data collection, formal analysis, writing—original draft preparation, writing—review and editing, funding acquisition, resources, supervision.

Corresponding author

Correspondence to Lisa M. Gudenkauf.

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Ethics approval and consent to participate

C-PRIME: Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life – Advarra Institutional Review Board (Pro00062245) / Moffitt MCC21751. All participants provided informed consent to participate in the current study.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Gudenkauf, L.M., Li, X., Hoogland, A.I. et al. Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer. Support Care Cancer 32, 198 (2024). https://doi.org/10.1007/s00520-024-08395-5

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