Abstract
Background
The disease burden attributable to chronic obstructive pulmonary disease (COPD) is significant worldwide. Some studies have linked exposure to air pollution to COPD, but there has been little research on this.
Methods
We aimed to assess the COPD-related disease burden attributable to air pollution from multiple epidemiological perspectives. This study conducted a three-stage analysis. Firstly, we reported on the burden of disease worldwide in 2019 by different subgroups including sex, age, region, and country. Secondly, we studied the trends in disease burden from 1990 to 2019. Finally, we explored the association of some national indicators with disease burden to look for risk factors.
Results
In 2019, the death number of COPD associated with air pollution accounted for 2.32% of the total global death, and the number of DALY accounted for 1.12% of the global DALY. From 1990 to 2019, the death number of COPD associated with air pollution increased peaked at 1.41 million in 1993, fluctuated, and then declined. We found the same temporal pattern of DALY. The corresponding age-standardized rates had been falling. At the same time, the burden of COPD associated with air pollution was also affected by some national indicators.
Conclusions
This study indicated that air pollution-related COPD contributed to a significant global disease burden. We called for health policymakers to take action and interventions targeting vulnerable countries and susceptible populations.
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Data availability
The data in this manuscript come from a public website.
Abbreviations
- COPD:
-
Chronic Obstructive Pulmonary Disease
- DALY:
-
Disability-Adjusted Life Year
- GBD 2019:
-
Global Burden of Disease Study 2019
- SDI:
-
Social Demographic Index
- EAPC:
-
Estimated Annual Percentage Change
References
Adam M, Schikowski T, Carsin AE, Cai Y, Jacquemin B, Sanchez M et al (2015) Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. Eur Respir J 45(1):38–50. https://doi.org/10.1183/09031936.00130014
Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sørensen M, Tjønneland A, Overvad K, Raaschou-Nielsen O (2011) Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study. Am J Respir Crit Care Med 183(4):455–461. https://doi.org/10.1164/rccm.201006-0937OC
Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R (2015) Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis 10:995–1013. https://doi.org/10.2147/copd.S82518
Balidemaj F, Isaxon C, Abera A, Malmqvist E (2021) Indoor Air Pollution Exposure of Women in Adama, Ethiopia, and Assessment of Disease Burden Attributable to Risk Factor. Int J Environ Res Public Health 18 (18). https://doi.org/10.3390/ijerph18189859
Barnes PJ (2007) Chronic obstructive pulmonary disease: a growing but neglected global epidemic. Plos Med 4(5):e112. https://doi.org/10.1371/journal.pmed.0040112
Behera D, Jindal SK (1991) Respiratory symptoms in Indian women using domestic cooking fuels. Chest 100(2):385–388. https://doi.org/10.1378/chest.100.2.385
Bernard C, Iburg K, Inoue M, Fat D, Shibuya K, Stein C, Tomijima N, Xu H (2004) The Global Burden of Disease in 2002: Data Sources, Methods and Results.
Brandsma CA, de Vries M, Costa R, Woldhuis RR, Königshoff M, Timens W (2017) Lung ageing and COPD: is there a role for ageing in abnormal tissue repair? Eur Respir Rev 26 (146). https://doi.org/10.1183/16000617.0073-2017
Bretó C, Ionides EL, King AA (2019) Panel Data Analysis via Mechanistic Models. J Am Stat Assoc 115(531):1178–1188. https://doi.org/10.1080/01621459.2019.1604367
Celli BR, Thomas NE, Anderson JA, Ferguson GT, Jenkins CR, Jones PW, Vestbo J, Knobil K, Yates JC, Calverley PM (2008) Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med 178(4):332–338. https://doi.org/10.1164/rccm.200712-1869OC
Chan-Yeung M, Aït-Khaled N, White N, Ip MS, Tan WC (2004) The burden and impact of COPD in Asia and Africa. Int J Tuberc Lung Dis 8(1):2–14
DeVries R, Kriebel D, Sama S (2017) Outdoor Air Pollution and COPD-Related Emergency Department Visits, Hospital Admissions, and Mortality: A Meta-Analysis. COPD 14(1):113–121. https://doi.org/10.1080/15412555.2016.1216956
Doiron D, de Hoogh K, Probst-Hensch N, Fortier I, Cai Y, De Matteis S, Hansell AL (2019) Air pollution, lung function and COPD: results from the population-based UK Biobank study. Eur Respir J 54 (1). https://doi.org/10.1183/13993003.02140-2018
Effatpanah M, Effatpanah H, Jalali S, Parseh I, Goudarzi G, Barzegar G, Geravandi S, Darabi F, Ghasemian N, Mohammadi MJ (2020) Hospital admission of exposure to air pollution in Ahvaz megacity during 2010–2013. Clin Epidemiol Global Health 8(2):550–556. https://doi.org/10.1016/j.cegh.2019.12.001
Eisner MD, Anthonisen N, Coultas D, Kuenzli N, Perez-Padilla R, Postma D, Romieu I, Silverman EK, Balmes JR (2010) An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 182(5):693–718. https://doi.org/10.1164/rccm.200811-1757ST
Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O’Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C (2014) Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet 383(9913):245–254. https://doi.org/10.1016/s0140-6736(13)61953-4
Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M et al (2015) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386(10010):2287–2323. https://doi.org/10.1016/s0140-6736(15)00128-2
Geravandi S, Goudarzi GR, VousoghiNiri M, Mohammadi MJ, Saeidimehr S, Geravandi S (2015) Estimate of cardiovascular and respiratory mortality related to Sulfur dioxide pollutant in Ahvaz. J Environ Stud 41(2):341–350. https://doi.org/10.22059/jes.2015.54985
Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE (2020) Air pollution and its effects on the immune system. Free Radic Biol Med 151:56–68. https://doi.org/10.1016/j.freeradbiomed.2020.01.179
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (10053):1545–1602. https://doi.org/10.1016/s0140-6736(16)31678-6
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 (2016). Lancet 388 (10053):1459–1544. https://doi.org/10.1016/s0140-6736(16)31012-1
Götschi T, Heinrich J, Sunyer J, Künzli N (2008) Long-term effects of ambient air pollution on lung function: a review. Epidemiology 19(5):690–701. https://doi.org/10.1097/EDE.0b013e318181650f
Goudarzi G, Geravandi S, Idani E, Hosseini SA, Baneshi MM, Yari AR, Vosoughi M, Dobaradaran S, Shirali S, Marzooni MB, Ghomeishi A, Alavi N, Alavi SS, Mohammadi MJ (2016) An evaluation of hospital admission respiratory disease attributed to sulfur dioxide ambient concentration in Ahvaz from 2011 through 2013. Environ Sci Pollut Res Int 23(21):22001–22007. https://doi.org/10.1007/s11356-016-7447-x
Goudarzi G, Alavi N, Geravandi S, Idani E, Behrooz HRA, Babaei AA, Alamdari FA, Dobaradaran S, Farhadi M, Mohammadi MJ (2018) Health risk assessment on human exposed to heavy metals in the ambient air PM(10) in Ahvaz, southwest Iran. Int J Biometeorol 62(6):1075–1083. https://doi.org/10.1007/s00484-018-1510-x
Guan WJ, Zheng XY, Chung KF, Zhong NS (2016) Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action. Lancet 388(10054):1939–1951. https://doi.org/10.1016/s0140-6736(16)31597-5
Guo C, Zhang Z, Lau AKH, Lin CQ, Chuang YC, Chan J, Jiang WK, Tam T, Yeoh EK, Chan TC, Chang LY, Lao XQ (2018) Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan: a longitudinal, cohort study. Lancet Planet Health 2(3):e114–e125. https://doi.org/10.1016/s2542-5196(18)30028-7
Hansel NN, McCormack MC, Kim V (2016) The Effects of Air Pollution and Temperature on COPD. COPD 13(3):372–379. https://doi.org/10.3109/15412555.2015.1089846
Hansel NN, Putcha N, Woo H, Peng R, Diette GB, Fawzy A, Wise RA, Romero K, Davis MF, Rule AM, Eakin MN, Breysse PN, McCormack MC, Koehler K (2022) Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study. Am J Respir Crit Care Med 205(4):421–430. https://doi.org/10.1164/rccm.202103-0604OC
Hendryx M, Luo J, Chojenta C, Byles JE (2019) Air pollution exposures from multiple point sources and risk of incident chronic obstructive pulmonary disease (COPD) and asthma. Environ Res 179(Pt A):108783. https://doi.org/10.1016/j.envres.2019.108783
Hu W, Fang L, Ni R, Zhang H, Pan G (2022a) Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years. BMC Cancer 22(1):836. https://doi.org/10.1186/s12885-022-09940-3
Hu W, Fang L, Zhang H, Ni R, Pan G (2022b) Global disease burden of COPD from 1990 to 2019 and prediction of future disease burden trend in China. Public Health 208:89–97. https://doi.org/10.1016/j.puhe.2022.04.015
Khaefi M, Geravandi S, Hassani G, Yari AR, Soltani F, Dobaradaran S, Moogahi S, Mohammadi MJ, Mahboubi M, Alavi N, Farhadi M, Khaniabadi YO (2017) Association of Particulate Matter Impact on Prevalence of Chronic Obstructive Pulmonary Disease in Ahvaz, Southwest Iran during 2009–2013. Aerosol Air Qual Res 17(1):230–237. https://doi.org/10.4209/aaqr.2015.11.0628
Khaniabadi YO, Daryanoosh SM, Hopke PK, Ferrante M, De Marco A, Sicard P, Oliveri Conti G, Goudarzi G, Basiri H, Mohammadi MJ, Keishams F (2017) Acute myocardial infarction and COPD attributed to ambient SO2 in Iran. Environ Res 156:683–687. https://doi.org/10.1016/j.envres.2017.04.028
Li S, Chen H, Man J, Zhang T, Yin X, He Q, Yang X, Lu M (2021) Changing trends in the disease burden of esophageal cancer in China from 1990 to 2017 and its predicted level in 25 years. Cancer Med 10(5):1889–1899. https://doi.org/10.1002/cam4.3775
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2224–2260. https://doi.org/10.1016/s0140-6736(12)61766-8
Liu Y, Lee K, Perez-Padilla R, Hudson NL, Mannino DM (2008) Outdoor and indoor air pollution and COPD-related diseases in high- and low-income countries. Int J Tuberc Lung Dis 12(2):115–127
López-Campos JL, Tan W, Soriano JB (2016) Global burden of COPD. Respirology 21(1):14–23. https://doi.org/10.1111/resp.12660
Lux H, Baur X, Budnik LT, Heutelbeck A, Teixeira JP, Neumann E, Adliene D, Puišo J, Lucas D, Löndahl J, Damialis A, Goksel O, Orru H (2020) Outdoor air pollution from industrial chemicals causing new onset of asthma or COPD: a systematic review protocol. J Occup Med Toxicol 15(1):38. https://doi.org/10.1186/s12995-020-00289-6
Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E (2020) Environmental and Health Impacts of Air Pollution: A Review. Front Public Health 8:14. https://doi.org/10.3389/fpubh.2020.00014
Martinez FJ, Curtis JL, Sciurba F, Mumford J, Giardino ND, Weinmann G, Kazerooni E, Murray S, Criner GJ, Sin DD, Hogg J, Ries AL, Han M, Fishman AP, Make B, Hoffman EA, Mohsenifar Z, Wise R (2007) Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med 176(3):243–252. https://doi.org/10.1164/rccm.200606-828OC
Matera MG, Ora J, Calzetta L, Rogliani P, Cazzola M (2021) Sex differences in COPD management. Expert Rev Clin Pharmacol 14(3):323–332. https://doi.org/10.1080/17512433.2021.1888713
Mehrotra A, Akanbi MO, Gordon SB (2009) The burden of COPD in Africa: a literature review and prospective survey of the availability of spirometry for COPD diagnosis in Africa. Trop Med Int Health 14(8):840–848. https://doi.org/10.1111/j.1365-3156.2009.02308.x
Mortimer K, Montes de Oca M, Salvi S, Balakrishnan K, Hadfield RM, Ramirez-Venegas A, Halpin DMG, Ozoh Obianuju B, Han MeiLan K, Perez Padilla R, Kirenga B, Balmes JR (2022) Household air pollution and COPD: cause and effect or confounding by other aspects of poverty? Int J Tuberc Lung Dis 26(3):206–216. https://doi.org/10.5588/ijtld.21.0570
Pauwels RA, Rabe KF (2004) Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364(9434):613–620. https://doi.org/10.1016/s0140-6736(04)16855-4
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH (2017) Understanding COPD-overlap syndromes. Expert Rev Respir Med 11(4):285–298. https://doi.org/10.1080/17476348.2017.1305895
Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2020). Lancet Respir Med 8 (6):585–596. https://doi.org/10.1016/s2213-2600(20)30105-3
Rabbani G, Shariful Islam SM, Rahman MA, Amin N, Marzan B, Robin RC, Alif SM (2021) Pre-existing COPD is associated with an increased risk of mortality and severity in COVID-19: a rapid systematic review and meta-analysis. Expert Rev Respir Med 15(5):705–716. https://doi.org/10.1080/17476348.2021.1866547
Raherison C, Girodet PO (2009) Epidemiology of COPD. Eur Respir Rev 18(114):213–221. https://doi.org/10.1183/09059180.00003609
Raparelli V, Palmieri L, Canevelli M, Pricci F, Unim B, Lo Noce C, Villani ER, Rochon PA, Pilote L, Vanacore N, Onder G (2020) Sex differences in clinical phenotype and transitions of care among individuals dying of COVID-19 in Italy. Biol Sex Differ 11(1):57. https://doi.org/10.1186/s13293-020-00334-3
Rice MB, Ljungman PL, Wilker EH, Dorans KS, Gold DR, Schwartz J, Koutrakis P, Washko GR, O’Connor GT, Mittleman MA (2015) Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study. Am J Respir Crit Care Med 191(6):656–664. https://doi.org/10.1164/rccm.201410-1875OC
Schikowski T, Adam M, Marcon A, Cai Y, Vierkötter A, Carsin AE et al (2014a) Association of ambient air pollution with the prevalence and incidence of COPD. Eur Respir J 44(3):614–626. https://doi.org/10.1183/09031936.00132213
Schikowski T, Mills IC, Anderson HR, Cohen A, Hansell A, Kauffmann F, Krämer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N (2014b) Ambient air pollution: a cause of COPD? Eur Respir J 43(1):250–263. https://doi.org/10.1183/09031936.00100112
Schraufnagel DE, Balmes JR, De Matteis S, Hoffman B, Kim WJ, Perez-Padilla R, Rice M, Sood A, Vanker A, Wuebbles DJ (2019) Health Benefits of Air Pollution Reduction. Ann Am Thorac Soc 16(12):1478–1487. https://doi.org/10.1513/AnnalsATS.201907-538CME
Shahriyari H, Nikmanesh Y, Jalali S, Tahery N, Fard A, Hatamzadeh N, Zarea K, Cheraghi M, Mohammadi M (2021) Air pollution and human health risks: mechanisms and clinical manifestations of cardiovascular and respiratory diseases. Toxin Rev:1–12. https://doi.org/10.1080/15569543.2021.1887261
Sharma AK, Kalra OP, Saini NK, Kelkar H (2019) Pilot Study of Chronic Obstructive Pulmonary Disease in an Industrial Town in India. J Health Pollut 9(21):190304. https://doi.org/10.5696/2156-9614-9.21.190304
Sheikh K, Coxson HO, Parraga G (2016) This is what COPD looks like. Respirology 21(2):224–236. https://doi.org/10.1111/resp.12611
Song J, Pan R, Yi W, Wei Q, Qin W, Song S, Tang C, He Y, Liu X, Cheng J, Su H (2021) Ambient high temperature exposure and global disease burden during 1990–2019: An analysis of the Global Burden of Disease Study 2019. Sci Total Environ 787:147540. https://doi.org/10.1016/j.scitotenv.2021.147540
Tahery N, Geravandi S, Goudarzi G, Shahriyari HA, Jalali S, Mohammadi MJ (2021) Estimation of PM(10) pollutant and its effect on total mortality (TM), hospitalizations due to cardiovascular diseases (HACD), and respiratory disease (HARD) outcome. Environ Sci Pollut Res Int 28(17):22123–22130. https://doi.org/10.1007/s11356-020-12052-9
The L (2018) GBD 2017: a fragile world. Lancet 392(10159):1683. https://doi.org/10.1016/s0140-6736(18)32858-7
Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187(4):347–365. https://doi.org/10.1164/rccm.201204-0596PP
Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiat 72(4):334–341. https://doi.org/10.1001/jamapsychiatry.2014.2502
Xie M, Liu X, Cao X, Guo M, Li X (2020) Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017. Respir Res 21(1):49. https://doi.org/10.1186/s12931-020-1291-8
Yin P, Brauer M, Cohen AJ, Wang H, Li J, Burnett RT, Stanaway JD, Causey K, Larson S, Godwin W, Frostad J, Marks A, Wang L, Zhou M, Murray CJL (2020) The effect of air pollution on deaths, disease burden, and life expectancy across China and its provinces, 1990–2017: an analysis for the Global Burden of Disease Study 2017. Lancet Planet Health 4(9):e386–e398. https://doi.org/10.1016/s2542-5196(20)30161-3
Zhu B, Wang Y, Ming J, Chen W, Zhang L (2018) Disease burden of COPD in China: a systematic review. Int J Chron Obstruct Pulmon Dis 13:1353–1364. https://doi.org/10.2147/copd.S161555
Funding
This study was supported by grants from the National Natural Science Foundation of China (No. 42105165) and High-level Scientific Research Foundation of Anhui Medical University (No. 0305044201).
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Guixia Pan. The first draft of the manuscript was written by Guixia Pan and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Pan, G., Cheng, J., Pan, HF. et al. Global Chronic obstructive pulmonary disease burden attributable to air pollution from 1990 to 2019. Int J Biometeorol 67, 1543–1553 (2023). https://doi.org/10.1007/s00484-023-02504-5
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DOI: https://doi.org/10.1007/s00484-023-02504-5