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Growth plate alterations in chronic kidney disease

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Abstract

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. To facilitate the understanding of the pathogenesis of growth impairment in CKD, this review discusses cellular and molecular alterations of the growth plate during uremia, including structural and dynamic changes of chondrocytes, alterations in their process of maturation and hypertrophy, and disturbances in the growth hormone signaling pathway.

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Acknowledgments

This work was supported by the National Plan I+D+I 2013-2016 Instituto de Salud Carlos III (PI15/02122), European Regional Development Funds 2013-2016 (ERDF, Grupín 14-020), and by the Foundation of the University of Oviedo (FUO).

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Authors and Affiliations

  1. Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain

    Ángela Fernández-Iglesias, José Manuel López & Fernando Santos

  2. Department of Morphology and Cellular Biology, Faculty of Medicine, University of Oviedo, Oviedo, Asturias, Spain

    José Manuel López

  3. Pediatric Nephrology, Department of Pediatrics, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain

    Fernando Santos

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  1. Ángela Fernández-Iglesias
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  2. José Manuel López
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  3. Fernando Santos
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Correspondence to Fernando Santos.

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Multiple choice answers: 1a, 2b, 3d, 4d, 5c

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Fernández-Iglesias, Á., López, J.M. & Santos, F. Growth plate alterations in chronic kidney disease. Pediatr Nephrol 35, 367–374 (2020). https://doi.org/10.1007/s00467-018-4160-7

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