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Efficacy of Growth Hormone Treatment in Children With Chronic Kidney Disease: Tunisian Experience

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Abstract

Objective

To study the effect of using recombinant human growth hormone (rhGH) in growth retarded children with chronic kidney disease (CKD)

Methods

This was a non-randomized controlled study over 2 years including children in CKD stages 4–5 suffering from growth retardation. Children were divided into rhGH-treated or non-rhGH treated groups.

Results

A total of 70 children (35 in each group) were enrolled. While the mean (SD) height of 35 children with CKD had increased from 109.5 (26) cm to 116 (26) cm (mean growth velocity 6.5 cm/year; P=0.09) prior to rhGH therapy, the same was found to increase from 116 (26) cm at the start of therapy to 125 (25) cm after one year of therapy (P=0.02).

Conclusions

Therapy with rhGH was helpful in catch-up growth in Tunisian children with CKD.

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Funding

Funding: None

Author information

Authors and Affiliations

  1. Pediatric Nephrology Department, Charles Nicolle Hospital, Tunis, Tunisia

    Abir Boussetta, M. Jellouli, O. Naija & T. Gargah

  2. Faculty of Medicine of Tunis, Tunis, Tunisia

    R. Laamouri

  3. University of Tunis El Manar, Tunis, Tunisia

    Abir Boussetta, R. Laamouri, M. Jellouli, O. Naija & T. Gargah

Authors
  1. Abir Boussetta
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  2. R. Laamouri
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  3. M. Jellouli
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  4. O. Naija
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  5. T. Gargah
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Contributions

Contributors: AB: concept and designed the study, analyzed data and drafted the manuscript; RL: collected the data, helped in data analysis; MJ: helped in collecting data, and manuscript drafting; ON: supervised cognitive and behavioral assessments; TG: supervised cognitive and behavioral assessments

Corresponding author

Correspondence to Abir Boussetta.

Ethics declarations

Ethics clearance: Ethic committee of Charles Nicolle Hospital; No. Tun23032016, dated March 23, 2016.

Competing interest: None stated.

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Boussetta, A., Laamouri, R., Jellouli, M. et al. Efficacy of Growth Hormone Treatment in Children With Chronic Kidney Disease: Tunisian Experience. Indian Pediatr 58, 1140–1142 (2021). https://doi.org/10.1007/s13312-021-2395-z

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  • DOI: https://doi.org/10.1007/s13312-021-2395-z

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