Abstract
Background
Outcomes are not well studied in patients undergoing remediation for multi-fundoplication failure, that is, two or more prior failed fundoplications. Re-operation must balance reflux control and restoration of the ability to eat with the challenge of reconstructing a distorted hiatus and GE junction. The purpose of this study is to present our experience with surgical remediation for multi-fundoplication failure.
Methods
Medical records were retrospectively reviewed of 91 patients who underwent third time or more esophagogastric operation for fundoplication failure at a single institution from 2007 to 2016. Dysphagia was present in 56% and heartburn in 51%. Median number of prior operations was 2 with range up to 6. Anatomic failure consisted of slipped wrap in 26 cases, wrap herniation in 23, hiatal stenosis in 24, hiatal mesh complication in 8, and wrap dehiscence in 10. Operative approaches generally followed an institutional algorithm and consisted of hiatal hernia repair with: re-do fundoplication in 55%, takedown of fundoplication alone in 24%, Roux-en-Y gastrojejunostomy in 14%, and GE junction resection in 7%. Laparoscopic approach was successful in 81%.
Results
Mean duration of operations was 217 min and median length of stay was 3 days. The complication rate was 13%, with 7% undergoing unplanned early re-operation. Patients were followed for mean 11 months, and recurrent hiatal hernia was detected in 13%. Late re-operation was performed in 6% for recurrent hiatal hernia. Recurrent reflux symptomatology resolved in 93%. Dysphagia resolved in 84%. There were no significant differences in outcomes with regard to number of prior operations, operative approach, BMI, or age.
Conclusions
There is no single best approach to remediation in the multi-fundoplication failure patient. Re-do fundoplication is appropriate in over half of patients. Reoperation for multi-fundoplication failure can be performed via minimally invasive approach with excellent remediation of symptoms, low morbidity, and low recurrence rates.
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All listed authors made substantial contributions to the conception and design of this work as well as acquisition, analysis, and interpretation of data. All revised critically for important intellectual content. All gave final approval for publishing. All agree to be accountable for all aspects of the work to ensure questions related to accuracy/integrity of any part are appropriately investigated and resolved.
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Drs. Michael Antiporda, C. Daniel Smith, Mathew Thomas, Enrique Elli, Steven P. Bowers, and Ms. Chloe Jackson have no relevant conflicts of interest or financial ties to disclose.
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Antiporda, M., Jackson, C., Smith, C.D. et al. Strategies for surgical remediation of the multi-fundoplication failure patient. Surg Endosc 33, 1474–1481 (2019). https://doi.org/10.1007/s00464-018-6429-0
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DOI: https://doi.org/10.1007/s00464-018-6429-0