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Long-term outcomes of laparoscopic cholecystectomy: a prospective piecewise linear regression analysis

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Abstract

Background

The objectives of this study were to examine longitudinal time trends, to predict thresholds of improvement in each dimension of health-related quality of life (HRQoL), and to identify long-term predictors of HRQoL.

Methods

This study analyzed 353 laparoscopic cholecystectomy (LC) patients. Disease-specific Gastrointestinal Quality-of-Life Index (GIQLI) and generic Short-Form 36-Item Health Survey (SF-36) scores were obtained immediately before surgery, then 3, 6, 12, and 24 months after surgery. Generalized estimating equations and piecewise linear regression models were used.

Results

The examined population significantly (p < 0.05) improved in both SF-36 and GIQLI subscale scores. The HRQoL dimensions were substantially improved the sixth month after surgery and continued improving until they reached a plateau at 54.93 to 73.18 months. The data also showed the following explanatory variables for HRQoL: time, age, gender, Charlson Comorbidity Index, and preoperative GIQLI and SF-36 subscale scores.

Conclusions

As shown by the findings, the HRQoL scores improved substantially by the sixth month after surgery and continued improving until they reached a 4- to 7-year threshold, indicating that change trends in HRQoL dimensions may vary. Although HRQoL scores were substantially improved after cholecystectomy, the improvements were associated with preoperative functional status and demographic characteristics.

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Disclosures

Hon-Yi Shi, Hao-Hsien Lee, Meng-Han Tsai, Chong-Chi Chiu, Yih-Huei Uen, and King-Teh Lee have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Graduate Institute of Healthcare Administration, Kaohsiung Medical University, 100-Shih-Chun 1st Road, Kaohsiung, Taiwan

    Hon-Yi Shi, Meng-Han Tsai & King-Teh Lee

  2. Department of Surgery, Chi Mei Medical Center, Liou Ying Campus, Tainan, Taiwan

    Hao-Hsien Lee & Chong-Chi Chiu

  3. Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan

    Yih-Huei Uen

  4. Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    King-Teh Lee

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  1. Hon-Yi Shi
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  2. Hao-Hsien Lee
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  3. Meng-Han Tsai
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  4. Chong-Chi Chiu
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  5. Yih-Huei Uen
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  6. King-Teh Lee
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Correspondence to King-Teh Lee.

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Shi, HY., Lee, HH., Tsai, MH. et al. Long-term outcomes of laparoscopic cholecystectomy: a prospective piecewise linear regression analysis. Surg Endosc 25, 2132–2140 (2011). https://doi.org/10.1007/s00464-010-1508-x

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  • DOI: https://doi.org/10.1007/s00464-010-1508-x

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