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Smell with new neurons

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Abstract

In this minireview, we briefly describe some recent discoveries of new neurons that are generated inside adult mammalian olfactory circuits and that might affect olfactory function and related behaviors. These studies indicate potential new directions for the investigation of olfactory perception, the examination of olfactory disorders, and the development of related treatments.

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References

  • Altman J (1962) Are new neurons formed in the brains of adult mammals? Science 135:1127–1128

    Article  CAS  PubMed  Google Scholar 

  • Bernier PJ, Bedard A, Vinet J, Levesque M, Parent A (2002) Newly generated neurons in the amygdala and adjoining cortex of adult primates. Proc Natl Acad Sci USA 99:11464–11469

    Article  CAS  PubMed  Google Scholar 

  • Bordey A (2007) Enigmatic GABAergic networks in adult neurogenic zones. Brain Res Rev 53:124–134

    Article  CAS  PubMed  Google Scholar 

  • Breton-Provencher V, Lemasson M, Peralta MR 3rd, Saghatelyan A (2009) Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors. J Neurosci 29:15245–15257

    Article  CAS  PubMed  Google Scholar 

  • Chen WR, Shepherd GM (2005) The olfactory glomerulus: a cortical module with specific functions. J Neurocytol 34:353–360

    Article  PubMed  Google Scholar 

  • Edden RAE, Muthukumaraswamy SD, Freeman TCA, Singh KD (2009) Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. J Neurosci 29:15721–15726

    Article  CAS  PubMed  Google Scholar 

  • Eisch AJ, Harburg GC (2006) Opiates, psychostimulants, and adult hippocampal neurogenesis: insights for addiction and stem cell biology. Hippocampus 16:271–286

    Article  CAS  PubMed  Google Scholar 

  • Fowler CD, Liu Y, Ouimet C, Wang Z (2002) The effects of social environment on adult neurogenesis in the female prairie vole. J Neurobiol 51:115–128

    Article  PubMed  Google Scholar 

  • Fowler CD, Liu Y, Wang Z (2008) Estrogen and adult neurogenesis in the amygdala and hypothalamus. Brains Res Rev 57:342–351

    Article  CAS  Google Scholar 

  • Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, Yamaguchi M, Mori K, Ikeda T, Itohara S, Kageyama R (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11:1153–1161

    Article  CAS  PubMed  Google Scholar 

  • Inta D, Alfonso J, von Engelhardt J, Kreuzberg MM, Meyer AH, van Hooft JA, Monyer H (2008) Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc Natl Acad Sci USA 105:20994–20999

    Article  CAS  PubMed  Google Scholar 

  • Kaplan MS, Hinds JW (1977) Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197:1092–1094

    Article  CAS  PubMed  Google Scholar 

  • Kelsch W, Lin CW, Mosley CP, Lois C (2009) A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis. J Neurosci 29:11852–11858

    Article  CAS  PubMed  Google Scholar 

  • Kempermann G, Gast D, Gage FH (2002) Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 52:135–143

    Article  PubMed  Google Scholar 

  • Kuhn HG, Dickinson-Anson H, Gage FH (1996) Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 16:2027–2033

    CAS  PubMed  Google Scholar 

  • Lagier S, Carleton A, Lledo PM (2004) Interplay between local GABAergic interneurons and relay neurons generates gamma oscillations in the rat olfactory bulb. J Neurosci 24:4382–4392

    Article  CAS  PubMed  Google Scholar 

  • Lazarini F, Mouthon MA, Gheusi G, de Chaumont F, Olivo-Marin JC, Lamarque S, Abrous DN, Boussin FD, Lledo PM (2009) Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PLoS ONE 4:e7017

    Article  PubMed  Google Scholar 

  • Leuner B, Kozorovitskiy Y, Gross CG, Gould E (2007) Diminished adult neurogenesis in the marmoset brain precedes old age. Proc Natl Acad Sci USA 104:17169–17173

    Article  CAS  PubMed  Google Scholar 

  • Loseva E, Yuan TF, Karnup S (2009) Neurogliogenesis in the mature olfactory system: a possible protective role against infection and toxic dust. Brain Res Rev 59:374–387

    Article  PubMed  Google Scholar 

  • Moreno MM, Linster C, Escanilla O, Sacquet J, Didier A, Mandairon N (2009) Olfactory perceptual learning requires adult neurogenesis. Proc Natl Acad Sci USA 106:17980–17985

    Article  CAS  PubMed  Google Scholar 

  • Mouret A, Murray K, Lledo PM (2009) Centrifugal drive onto local inhibitory interneurons of the olfactory bulb. Ann N Y Acad Sci 1170:239–254

    Article  CAS  PubMed  Google Scholar 

  • Nissant A, Bardy C, Katagiri H, Murray K, Lledo PM (2009) Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nat Neurosci 12:728–730

    Article  CAS  PubMed  Google Scholar 

  • Ortega-Perez I, Murray K, Lledo PM (2007) The how and why of adult neurogenesis. J Mol Histol 38:555–562

    Article  PubMed  Google Scholar 

  • Panzanelli P, Bardy C, Nissant N, Pallotto M, Sassoe-Pognetto M, Lledo PM, Fritschy JM (2009) Early synapse formation in developing interneurons of the adult olfactory bulb. J Neurosci 29:15039–15052

    Article  CAS  PubMed  Google Scholar 

  • Perera TD, Park S, Nemirovskaya Y (2008) Cognitive role of neurogenesis in depression and antidepressant treatment. Neuroscientist 14:326–338

    Article  PubMed  Google Scholar 

  • Pierce AA, Xu AW (2010) De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci 30:723–730

    Article  CAS  PubMed  Google Scholar 

  • van Praag H, Shubert T, Zhao C, Gage FH (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680–8685

    Article  PubMed  Google Scholar 

  • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809

    Article  CAS  PubMed  Google Scholar 

  • Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, Garcia AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci USA 103:17501–17506

    Article  CAS  PubMed  Google Scholar 

  • Schoppa NE, Urban NN (2003) Dendritic processing within olfactory bulb circuits. Trends Neurosci 26:501–506

    Article  CAS  PubMed  Google Scholar 

  • Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE (2007) Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct Funct 212:133–148

    Article  PubMed  Google Scholar 

  • Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E (2001) Neurogenesis in the adult is involved in the formation of trace memories. Nature 410:372–376

    Article  CAS  PubMed  Google Scholar 

  • Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E (2002) Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12:578–584

    Article  PubMed  Google Scholar 

  • Valley MT, Mullen TR, Schultz LC, Sagdullaev BT, Firestein S (2009) Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfactory fear conditioning. Front Neurogenesis 1:1–13

    Article  Google Scholar 

  • Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16:296–304

    Article  PubMed  Google Scholar 

  • Yeshurun Y, Sobel N (2010) An odor is not worth a thousand words: from multidimensional odors to unidimensional odor objects. Annu Rev Psychol 61(219–241):C211–C215

    Google Scholar 

  • Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:645–660

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. NCI, People’s Republic of China

    Ti-Fei Yuan

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  1. Ti-Fei Yuan
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Correspondence to Ti-Fei Yuan.

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Yuan, TF. Smell with new neurons. Cell Tissue Res 340, 211–214 (2010). https://doi.org/10.1007/s00441-010-0964-x

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  • DOI: https://doi.org/10.1007/s00441-010-0964-x

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