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Long non-coding RNAs: a valuable biomarker for metabolic syndrome

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Abstract

Long non-coding RNAs (lncRNAs) have become important regulators of gene expression because they affect a wide range of biological processes, such as cell growth, death, differentiation, and aging. More and more evidence suggests that lncRNAs play a role in maintaining metabolic homeostasis. When certain lncRNAs are out of balance, metabolic disorders like diabetes, obesity, and heart disease get worse. In this review, we talk about what we know about how lncRNAs control metabolism, with a focus on diseases caused by long-term inflammation and the characteristics of the metabolic syndrome. We looked at lncRNAs and their molecular targets in the pathogenesis of signaling pathways. We also talked about how lncRNAs are becoming more and more interesting as diagnostic and therapeutic targets for improving metabolic homeostasis.

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Acknowledgements

We would like to thank Fatemeh Shajiee for designing the figures.

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Authors and Affiliations

  1. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Rashidmayvan & Majid Ghayour-Mobarhan

  2. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Reza Sahebi

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  1. Mohammad Rashidmayvan
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Correspondence to Majid Ghayour-Mobarhan.

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Rashidmayvan, M., Sahebi, R. & Ghayour-Mobarhan, M. Long non-coding RNAs: a valuable biomarker for metabolic syndrome. Mol Genet Genomics 297, 1169–1183 (2022). https://doi.org/10.1007/s00438-022-01922-1

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