Abstract
Purpose
Increased levels of tumor marker in intra-operative peritoneal lavage are associated with an earlier detection of recurrent peritoneal dissemination.
Method
Intra-operative peritoneal lavage samples from 193 patients with gastric cancer were obtained to determine the levels of the tumor markers, carcinoembryonic antigen (CEA) and cancer-related antigen 72-4 (CA72-4) using a chemiluminescent enzyme immunoassay.
Results
The peritoneal lavage CEA (CY-CEA), CA72-4 (CY-CA72-4) and serosal invasion were independent factors predicting the peritoneal dissemination including CY(+). The patients were divided into four groups on the basis of peritoneal lavage tumor marker status; group A: CY-CEA (−), CY-CA72-4 (−) group (CEA < 0.5 ng/ml, CA72-4 < 1.3 U/ml); group B: CY-CEA (−), CY-CA72-4 (+) group (CEA < 0.5 ng/ml, CA72-4 ≥ 1.3 U/ml); group C: CY-CEA (+), CY-CA72-4 (−) group (CEA ≥ 0.5 ng/ml, CA72-4 < 1.3 U/ml); and group D: CY-CEA (+), CY-CA72-4 (+) group (CEA ≥ 0.5 ng/ml, CA72-4 ≥ 1.3 U/ml). The 5-year survival among the patients in groups A, B, C and D was 87, 68, 38 and 20 %, respectively (p < 0.0001).
Conclusion
Combined analysis of these markers is therefore considered to be helpful for accurately determining sites of recurrence and the prognosis in advanced gastric cancer patients.
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Abbreviations
- CY(+):
-
Peritoneal lavage cytological positive
- CEA:
-
Carcinoembryonic antigen
- CA72-4:
-
Cancer-related antigen 72-4
- CA125:
-
Cancer antigen 125
- CY-CEA:
-
The peritoneal lavage carcinoembryonic antigen
- CY-CA72-4:
-
The peritoneal lavage cancer-related antigen 72-4
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Yamamoto, M., Yoshinaga, K., Matsuyama, A. et al. CEA/CA72-4 levels in peritoneal lavage fluid are predictive factors in patients with gastric carcinoma. J Cancer Res Clin Oncol 140, 607–612 (2014). https://doi.org/10.1007/s00432-014-1601-y
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DOI: https://doi.org/10.1007/s00432-014-1601-y