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Case report: pseudoendocrine sarcoma, a clinicopathologic report of a newly described soft tissue neoplasm

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Abstract

Papke et al. recently reported a series of twenty-three soft tissue lesions chiefly arising in older adults featuring distinct morphological and genetic characteristics. Pseudoendocrine sarcoma (PS) is the somewhat descriptive and provisional term adopted for the newly reported mesenchymal neoplasm. Since the publication of the original paper published in January 2022, a single case of PS has been published. Pseudoendocrine sarcoma shows a predilection for the paravertebral deep soft tissues of the trunk, low-grade neuroendocrine-like histological features, and hallmark CTNNB1 activating mutations.

Herein, we will discuss a case of a 72-year-old woman presenting with a 4-cm laterocervical mass. Hematoxylin and eosin slides showed a multilobular proliferation of monomorphic epithelioid cells with speckled chromatin arranged in nests and trabeculae. Immunohistochemical staining and molecular analysis were consistent with the newly proposed entity.

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Authors and Affiliations

  1. Department of Medicine, University of Padua School of Medicine, Via Gabelli, 61, Padua, 35121, Italy

    Elena Bellan, Angelo P. Dei Tos & Marta Sbaraglia

  2. Department of Integrated Diagnostics, Azienda Ospedale-Università Padova, Padua, Italy

    Elena Bellan, Angelo P. Dei Tos & Marta Sbaraglia

  3. Department of Pathology, Azienda ULSS 2 “Marca Trevigiana”, Treviso, Italy

    Francesca Zanco, Francesca Baciorri & Luisa Toffolatti

Authors
  1. Elena Bellan
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  2. Francesca Zanco
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  3. Francesca Baciorri
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  4. Luisa Toffolatti
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  5. Angelo P. Dei Tos
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  6. Marta Sbaraglia
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Contributions

Elena Bellan, Angelo. P. Dei Tos, and Marta Sbaraglia contributed to the writing of the manuscript. Luisa Toffolatti contributed by performing and interpreting the results of molecular analysis. Francesca Zanco and Francesca Baciorri discussed the results and commented on the manuscript. All authors approved the final version of the manuscript submitted.

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Correspondence to Marta Sbaraglia.

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Bellan, E., Zanco, F., Baciorri, F. et al. Case report: pseudoendocrine sarcoma, a clinicopathologic report of a newly described soft tissue neoplasm. Virchows Arch 482, 1057–1063 (2023). https://doi.org/10.1007/s00428-022-03476-4

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  • DOI: https://doi.org/10.1007/s00428-022-03476-4

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